Preclinical In Vivo Oncology Scientist

Novartis; Cambridge (MA); On-site; USD 58,000 - 107,000; Full time

Benefits offered by this job

Insurance plans

Retirement plans

Wellbeing resources

Global recognition programs

Hybrid working options

Parental leave

Job summary

Novartis Cambridge is seeking a scientist with hands-on in vivo pharmacology to design and lead preclinical oncology studies. You will test drug exposure, target engagement, PD responses and anti-tumor efficacy, integrating in vivo and ex vivo data to guide multidisciplinary teams.

The role requires strong mouse handling skills, proficiency in protein-based assays (MSD/ELISA/Western blot) and independent study design.

Qualifications

• Bachelor's or Master's degree in pharmacology, biology, cancer biology, molecular biology or a related scientific subject.
• Relevant industry or academic research experience demonstrating scientific independence.
• Strong hands-on experience with mouse studies, including dosing, tumour implantation, animal monitoring and sample collection.
• Hands-on experience with protein-based assays such as MSD, ELISA and Western blot.
• Demonstrated ability to independently design, execute, analyze and troubleshoot in vivo pharmacology studies.
• Strong attention to detail and organizational skills.
• Strong scientific judgement and ability to translate questions into testable hypotheses.

Responsibilities

• Independently design, plan and execute preclinical in vivo oncology studies to test hypotheses.
• Perform animal procedures such as dosing, tumor implantation, monitoring and sample collection.
• Establish tumor models for efficacy and PK/PD studies.
• Define study objectives and experimental strategies including dose, schedules and controls.
• Develop and troubleshoot protein-based pharmacodynamic assays (MSD, ELISA, Western blot).
• Design and interpret RNA-based gene-expression analyses alongside protein measurements.
• Oversee tumor and tissue processing and ensure reliable workflows.
• Integrate efficacy, exposure and PD datasets to evaluate relationships.
• Document experiments in the electronic lab notebook; report findings to teams.

Skills

In vivo pharmacology

Mouse studies

Protein assays

Data interpretation

Scientific independence

Attention to detail

Collaboration

Education

Bachelor's or Master's in pharmacology or biology

Tools

MSD assays

ELISA

Western blot

Job description

Novartis Cambridge is seeking a scientist with hands-on in vivo pharmacology to design and lead preclinical oncology studies. You will test drug exposure, target engagement, PD responses and anti-tumor efficacy, integrating in vivo and ex vivo data to guide multidisciplinary teams.

The role requires strong mouse handling skills, proficiency in protein-based assays (MSD/ELISA/Western blot) and independent study design.