Oligonucleotide Synthesis & Purification Process Scientist

LabRulez; Louisville, Northern (KY, KY); Hybrid; USD 120,000 - 180,000; Full time

Benefits offered by this job

Medical, dental, and vision coverage

Life and disability insurance

401(k) with company match

Paid vacation and holidays

Job summary

Eurofins USA Genomic Services is seeking a Synthetic DNA Process Development Scientist to design, develop and scale chemical processes for oligonucleotide production. The role emphasizes solid‑phase synthesis, purification optimization, and process transfers to manufacturing.

The candidate will work with QC, manufacturing and engineering to implement high-throughput approaches in regulated environments, with emphasis on yield, purity and compliance.

Qualifications

• Ph.D. or Master’s degree in Organic Chemistry or related field (required).
• Minimum 5 years of industrial experience in chemical synthesis.
• Hands-on experience with solid-phase oligonucleotide synthesis.
• Hands-on experience in oligonucleotide purification process development.
• Strong analytical skills (HPLC, LC-MS).
• Experience scaling processes to manufacturing.
• Experience in GMP or regulated environments, preferred.
• Familiarity with automated DNA/RNA synthesizers, strongly preferred.
• Knowledge of modified nucleotides, strongly preferred.
• Experience in high-throughput oligo production, strongly preferred.

Responsibilities

• Design, develop, and optimize chemical synthesis processes for nucleotides and oligonucleotides.
• Process development and scale-up from R&D to manufacturing.
• Develop and improve oligonucleotide purification processes (e.g., HPLC, ion-exchange, desalting).
• Troubleshoot synthesis and purification challenges to improve yield and purity.
• Collaborate with manufacturing, QC, and engineering for process transfer.
• Evaluate new chemistries and technologies.
• Author SOPs, batch records, and technical reports.
• Ensure compliance with quality systems.

Skills

Solid-phase oligonucleotide synthesis

HPLC

LC-MS

Process development

GMP experience

High-throughput oligo production

Education

Ph.D. or Master’s in Organic Chemistry

Tools

Automated DNA/RNA synthesizers

Oligonucleotide purification technologies

Job description

Eurofins USA Genomic Services is seeking a Synthetic DNA Process Development Scientist to design, develop and scale chemical processes for oligonucleotide production. The role emphasizes solid‑phase synthesis, purification optimization, and process transfers to manufacturing.

The candidate will work with QC, manufacturing and engineering to implement high-throughput approaches in regulated environments, with emphasis on yield, purity and compliance.