Synthetic DNA Process Development Scientist

LabRulez; Louisville, Northern (KY, KY); Hybrid; USD 120,000 - 180,000; Full time

Benefits offered by this job

Medical, dental, and vision coverage

Life and disability insurance

401(k) with company match

Paid vacation and holidays

Job summary

Eurofins USA Genomic Services is seeking a Synthetic DNA Process Development Scientist to design, develop and scale chemical processes for oligonucleotide production. The role emphasizes solid‑phase synthesis, purification optimization, and process transfers to manufacturing.

The candidate will work with QC, manufacturing and engineering to implement high-throughput approaches in regulated environments, with emphasis on yield, purity and compliance.

Qualifications

• Ph.D. or Master’s degree in Organic Chemistry or related field (required).
• Minimum 5 years of industrial experience in chemical synthesis.
• Hands-on experience with solid-phase oligonucleotide synthesis.
• Hands-on experience in oligonucleotide purification process development.
• Strong analytical skills (HPLC, LC-MS).
• Experience scaling processes to manufacturing.
• Experience in GMP or regulated environments, preferred.
• Familiarity with automated DNA/RNA synthesizers, strongly preferred.
• Knowledge of modified nucleotides, strongly preferred.
• Experience in high-throughput oligo production, strongly preferred.

Responsibilities

• Design, develop, and optimize chemical synthesis processes for nucleotides and oligonucleotides.
• Process development and scale-up from R&D to manufacturing.
• Develop and improve oligonucleotide purification processes (e.g., HPLC, ion-exchange, desalting).
• Troubleshoot synthesis and purification challenges to improve yield and purity.
• Collaborate with manufacturing, QC, and engineering for process transfer.
• Evaluate new chemistries and technologies.
• Author SOPs, batch records, and technical reports.
• Ensure compliance with quality systems.

Skills

Solid-phase oligonucleotide synthesis

HPLC

LC-MS

Process development

GMP experience

High-throughput oligo production

Education

Ph.D. or Master’s in Organic Chemistry

Tools

Automated DNA/RNA synthesizers

Oligonucleotide purification technologies

Job description

Scientific and Research Fellow, Liquid chromatography, Liquid chromatography-mass spectrometry

Synthetic DNA Process Development Scientist

Eurofins Scientific is an international life sciences company, providing a unique range of analytical testing services to clients across multiple industries, to make life and our environment safer, healthier and more sustainable. From the food you eat, to the water you drink, to the medicines you rely on, Eurofins works with the biggest companies in the world to ensure the products they supply are safe, their ingredients are authentic and labelling is accurate. Eurofins believes it is a global leader in food, environmental, pharmaceutical and cosmetics products testing and in agroscience CRO services. It is also one of the global independent market leaders in certain testing and laboratory services for genomics, discovery pharmacology, forensics, CDMO, advanced material sciences and in the support of clinical studies.

In over 35 years, Eurofins has grown from one laboratory in Nantes, France to 61,000 staff across a decentralised and entrepreneurial network of ca. 900 laboratories in 61 countries. Eurofins companies offer a portfolio of over 200,000 analytical methods to evaluate the safety, identity, composition, authenticity, origin, traceability and purity of biological substances and products.

In 2025, Eurofins generated total revenues of EUR 7.296 billion, and has been among the best performing stocks in Europe over the past 20 years.

Synthetic DNA Process Development Scientist

Job Description

Synthetic DNA Process Development Scientist Include but are not Limited to the Following:

We are seeking a highly skilled and motivated Organic Chemist with expertise in oligonucleotide synthesis and purification to support process development and manufacturing. This role focuses on developing, optimizing, and scaling chemical processes for high-throughput and high-quality oligonucleotide production.

• Design, develop, and optimize chemical synthesis processes for nucleotides and oligonucleotides
• Process development and scale-up from R&D to manufacturing
• Develop and improve oligonucleotide purification processes (e.g., HPLC, ion-exchange, desalting)
• Troubleshoot synthesis and purification challenges to improve yield and purity
• Collaborate with manufacturing, QC, and engineering for process transfer
• Evaluate new chemistries and technologies
• Author SOPs, batch records, and technical reports
• Ensure compliance with quality systems

Qualifications

Basic Minimum Education Qualifications:

• Ph.D. or Master's degree in Organic Chemistry or related field (required)

Basic Minimum Work Requirements:

• Minimum 5 years of industrial experience in chemical synthesis
• Hands-on experience with solid-phase oligonucleotide synthesis
• Hands-on experience in oligonucleotide purification process development
• Strong analytical skills (HPLC, LC-MS)
• Experience scaling processes to manufacturing
• Experience in GMP or regulated environments, preferred
• Familiarity with automated DNA/RNA synthesizers, strongly preferred
• Knowledge of modified nucleotides, strongly preferred
• Experience in high-throughput oligo production, strongly preferred
• Authorization to work in the United States indefinitely without restriction or sponsorship.

The Ideal Candidates Possess the Following:

• Ability to manage multiple priorities
• Occasional off-hours support as needed

Additional Information

Position is full-timeworkingMonday - Friday 8:00am - 5:00pm, with overtime and weekend work as needed. Candidates currently living within a commutable distance of Louisville, KY are encouraged to apply.

• Excellent full-time benefits including comprehensive medical coverage, dental, and vision options
• Life and disability insurance
• 401(k) with company match
• Paid vacation and holidays

Eurofins USA Genomic Services is a Disabled and Veteran Equal Employment Opportunity employer.