Senior Associate Scientist

Integrated Resources, Inc ( IRI ); Cambridge (MA); On-site; USD 60,000 - 80,000; Full time

Job summary

A biotech company is seeking a laboratory technician in Cambridge, Massachusetts to support oligonucleotide synthesis and downstream processing. The ideal candidate will have a BS in Chemistry and extensive hands-on lab experience, particularly in analytical techniques. Responsibilities include technical lab support, analytical testing, and process optimization while maintaining high standards of documentation and safety. Good communication skills and teamwork are essential for success in this role.

Qualifications

• 3+ years laboratory experience, preferably in an industrial setting.
• Basic understanding of analytical techniques such as pH and HPLC.
• Knowledge of oligonucleotide manufacturing processes is a plus.
• Strong commitment to maintaining high laboratory standards.
• Proactive team player in dynamic environments.

Responsibilities

• Provide hands-on lab support for oligonucleotide synthesis.
• Conduct analytical testing using various techniques.
• Optimize manufacturing processes for contract support.
• Maintain laboratory documentation practices.

Skills

Laboratory experience

Analytical techniques

Oligonucleotide synthesis

Communication skills

Education

BS in Chemistry

Job description

Oligonucleotide synthesis and downstream processing, Analytical HPLC/LCMS/UV-vis

Summary of Key Responsibilities

• Hands‑on lab support and process development for the chemical synthesis and downstream processing of oligonucleotide-based drug substance
• Synthesis of oligonucleotides up to 11 mmol scale
• Downstream processing of oligonucleotides including prep‑HPLC, Ultrafiltration, annealing, concentration and Lyophilization
• In‑process analytical testing including AX‑HPLC, IPRP‑HPLC, LCMS, UV‑vis
• Technical support for optimization of contract manufacturing processes

Qualifications

• BS in Chemistry with 3+ years lab experience, preferably in an industrial setting.
• Basic understanding of analytical techniques (pH, osmolality, conductivity measurement, HPLC, LC‑MS etc.). Related hands‑on experience is preferred.
• Knowledge of oligonucleotide manufacture process including phosphoramidite chemistry, chromatography, ultrafiltration etc. is a plus.
• Experience in record‑keeping and excellent laboratory documentation practice are required. Strong commitment to high laboratory and scientific standard; ability to maintain a safe, clean, and orderly laboratory work environment; assist in routine lab and equipment maintenance.
• Good communication skills are a must for this position.
• The successful candidate must be a responsible and proactive individual who is able to work as a team player in a highly dynamic environment with aggressive timelines.