Oligonucleotide Process Development Engineer — Scale-Up

Synthego; Redwood City (CA); On-site; USD 120,000 - 180,000; Full time

Benefits offered by this job

Medical benefits

Dental benefits

Vision benefits

401k program

Catered meals

Parental leave

Flexible paid time off

Education reimbursement

Job summary

Synthego is a leading biotech company focused on enabling genome engineering at scale. We are seeking a motivated Process Development Engineer to advance oligonucleotide manufacturing, improve costs and timelines, and transfer technologies to production lines.

You will work with chemists, engineers, and scientists to scale synthesis and purification, analyze data, and document development efforts. You will contribute to quality, equipment qualification, and process improvements in a fast-paced

Qualifications

• BS in Chemistry, Chemical Engineering, Bio-engineering or a similar field.
• 2–5 years of industry experience in a research/manufacturing/production environment.
• Direct experience in synthesis and analysis of oligonucleotide products.
• Experience in data analysis with Python and SQL.
• Understanding of aseptic handling techniques and liquid handling.
• Experience with large-scale instrumentation (HPLC, synthesizers, TFF, liquid handlers).

Responsibilities

• Design, develop, and implement methods to scale oligonucleotide synthesis and purification.
• Synthesize, purify and analyze oligonucleotides to specifications using instrumentation.
• Analyze data from UV, chromatograms, and mass spectrometry to optimize conditions.
• Collaborate with Chemists, Engineers, and Scientists on development projects.
• Conduct experiments using automated instrumentation and liquid handling equipment.
• Write development protocols and reports and present findings to stakeholders.
• Perform IQ/OQ/PQ for new instrumentation.
• Contribute ideas to improve processes and maintain records.
• Assist with quality data management and SOPs, Batch Records, Change Control.
• Coordinate with vendors for reagents, consumables, or instrumentation.
• Train others on new processes and procedures.

Skills

Python

SQL

Data analysis

Interpersonal skills

Communication

Education

BS in Chemistry, Chemical Engineering, Bio-engineering

Tools

HPLC

Oligonucleotide synthesizers

Tangential flow filtration

Liquid handling systems

Job description

Synthego is a leading biotech company focused on enabling genome engineering at scale. We are seeking a motivated Process Development Engineer to advance oligonucleotide manufacturing, improve costs and timelines, and transfer technologies to production lines.

You will work with chemists, engineers, and scientists to scale synthesis and purification, analyze data, and document development efforts. You will contribute to quality, equipment qualification, and process improvements in a fast-paced