Oligonucleotide Process Development Scientist GMP Scale-Up

Eurofins Genomics Americas; Louisville (KY); On-site; USD 110,000 - 160,000; Full time

Benefits offered by this job

Medical coverage

Dental coverage

Vision coverage

Life insurance

Disability insurance

401(k) with company match

Paid vacation

Paid holidays

Job summary

Eurofins USA Genomic Services in Louisville, KY seeks a Synthetic DNA Process Development Scientist to design, optimize, and scale chemical processes for nucleotides and oligonucleotides. You will lead purification development and troubleshoot challenges to improve yield and purity.

The role requires 5+ years in chemical synthesis, hands-on oligo synthesis/purification, and experience with GMP environments. Occasional off-hours support and collaboration with manufacturing and QC are expected.

Qualifications

• Ph.D. or Master’s degree in Organic Chemistry or related field (required).
• Minimum 5 years of industrial experience in chemical synthesis.
• Hands‑on experience with solid‑phase oligonucleotide synthesis.
• Hands‑on experience in oligonucleotide purification process development.
• Strong analytical skills (HPLC, LC‑MS).
• Experience scaling processes to manufacturing.
• Experience in GMP or regulated environments, preferred.
• Familiarity with automated DNA/RNA synthesizers, strongly preferred.
• Knowledge of modified nucleotides, strongly preferred.
• Experience in high‑throughput oligo production, strongly preferred.
• Authorization to work in the United States indefinitely without restriction or sponsorship.

Responsibilities

• Design, develop, and optimize chemical synthesis processes for nucleotides and oligonucleotides.
• Process development and scale-up from R&D to manufacturing.
• Develop and improve oligonucleotide purification processes (e.g., HPLC, ion-exchange, desalting).
• Troubleshoot synthesis and purification challenges to improve yield and purity.
• Collaborate with manufacturing, QC, and engineering for process transfer.
• Evaluate new chemistries and technologies.
• Author SOPs, batch records, and technical reports.
• Ensure compliance with quality systems.
• Mentor lab technicians.

Skills

Oligonucleotide synthesis

Purification

HPLC LC-MS

Process development

Education

PhD in Organic Chemistry

MS in Organic Chemistry

Tools

Automated DNA/RNA synthesizers

HPLC

Ion-exchange chromatography

LC-MS

Job description

Eurofins USA Genomic Services in Louisville, KY seeks a Synthetic DNA Process Development Scientist to design, optimize, and scale chemical processes for nucleotides and oligonucleotides. You will lead purification development and troubleshoot challenges to improve yield and purity.

The role requires 5+ years in chemical synthesis, hands-on oligo synthesis/purification, and experience with GMP environments. Occasional off-hours support and collaboration with manufacturing and QC are expected.