Senior Oligo Process Engineer – GMP Manufacturing

Illumina, Inc.; San Diego (CA); On-site; USD 98,000 - 148,000; Full time

Job summary

Illumina, Inc. in San Diego, CA is seeking a Process Engineer to join the Manufacturing Technology & Transfer team, developing and deploying oligonucleotide manufacturing processes in a GMP setting.

You will partner with development, Quality, Production, and Supply Chain to transfer sustainable processes. Typically requires 5 years of oligonucleotide experience with a BS or 3+ years with an MS/PhD in Chemistry/ Biochemistry/ Chemical Engineering or related field.

Qualifications

• Minimum 5 years oligonucleotide experience with a relevant degree.
• Experience with GMP environments and 21 CFR Part 11 is preferred.
• Ability to work across multiple departments and manage competing priorities.

Responsibilities

• Execute feasibility and development oligonucleotide builds for project timelines.
• Define technical requirements for new production equipment and processes.
• Author procedures and train operators to manufacture GMP products.
• Troubleshoot yield, quality, and throughput issues in production.
• Design and analyze controlled experiments to optimize processes and scale.
• Document results and provide actionable recommendations.
• Represent Oligo MTT on NPI core teams and transfer knowledge to production.
• Ensure successful transfer of processes to manufacturing support teams.

Skills

Oligonucleotide processes

Statistical Process Control

DOE techniques

cGMP compliance

High volume production

Cross-functional collaboration

Verbal & written communication

ERP systems

Synthesis equipment handling

Education

Bachelor’s degree in Chemistry/ Biochemistry/ Chemical Engineering or related

Master’s or PhD with related experience

Tools

Synthesis equipment

HPLC (Analytical/Preparative)

Mass spectrometry (MS)

UV spectroscopy

ERP software

Job description

Illumina, Inc. in San Diego, CA is seeking a Process Engineer to join the Manufacturing Technology & Transfer team, developing and deploying oligonucleotide manufacturing processes in a GMP setting.

You will partner with development, Quality, Production, and Supply Chain to transfer sustainable processes. Typically requires 5 years of oligonucleotide experience with a BS or 3+ years with an MS/PhD in Chemistry/ Biochemistry/ Chemical Engineering or related field.