Oligonucleotide Chemistry Scientist — Scale-Up & Innovation

Tessera Therapeutics; Somerville (MA); On-site; USD 90,000 - 108,000; Full time

Job summary

Tessera Therapeutics is seeking a skilled professional in Somerville, MA to perform small-scale, high-throughput production of guide RNA and optimize synthesis/purification methods for scalable manufacturing.

You will collaborate with the Internal Manufacturing team during process transfer and participate in cross-functional teams while documenting results. Strong communication and teamwork are essential for success.

Qualifications

• BS/MS in Chemistry, Biochemistry, Chemical Engineering, or related field with 5+ years (BS) or 3+ years (MS) of relevant industry experience
• Experience with upstream and downstream processing of oligonucleotides
• Must have experience with Mermade192 and Mermade12 synthesizers
• Äkta100 oligonucleotide synthesizer is a plus
• Experience with HPLC purification and analytics of guide RNA preferred
• Experience with enzymatic ligation techniques is a plus
• Experience using ELNs to document experimental results is a plus

Responsibilities

• Performing small scale, high throughput internal production of guide RNA to support platform research and pre-clinical activities
• Optimizing synthetic reactions and purification methods of drug candidates to ensure scalable and cost-effective processes for oligonucleotide manufacturing
• Working in collaboration with the Internal Manufacturing team during process transfer
• Participating in cross-functional teams and training to gain familiarity in all stages of oligonucleotide research and manufacturing

Skills

Oligonucleotide processing

Mermade192

Mermade12

Äkta100

HPLC purification

RNA analytics

Enzymatic ligation

ELNs documentation

Education

BS/MS in Chemistry/Biochemistry/Chemical Engineering

Tools

Mermade192

Mermade12

Äkta100

HPLC

Job description

Tessera Therapeutics is seeking a skilled professional in Somerville, MA to perform small-scale, high-throughput production of guide RNA and optimize synthesis/purification methods for scalable manufacturing.

You will collaborate with the Internal Manufacturing team during process transfer and participate in cross-functional teams while documenting results. Strong communication and teamwork are essential for success.