Neuroscience Discovery Scientist - iPSC Biology

Bristol Myers Squibb; Massachusetts; Presencial; USD 105.000 - 127.000; Jornada completa

Descripción de la vacante

Bristol Myers Squibb, Cambridge Crossing, MA, is seeking a Senior Associate Scientist - In vitro Biology in Neuroscience Discovery to advance novel targets using human iPSC-based models. You will design disease-relevant assays and collaborate across Discovery Biology to translate biology into therapeutic hypotheses.

The ideal candidate has strong molecular and cellular biology expertise and experience translating biological questions into meaningful therapeutic hypotheses.

Formación

• Bachelor's degree with 4+ years of academic and/or industry experience.
• Master's degree with 2+ years of academic and/or industry experience.
• Degree in neuroscience, biology, molecular biology, or related discipline.
• Strong foundation in molecular and cellular biology.
• Experience developing and applying cellular assays for target validation, pharmacological characterization, and/or compound profiling.
• Hands-on experience with human iPSC-derived neural and/or glial models and their application to neurodegenerative disease research.

Responsabilidades

• Design and execute hypothesis-driven studies to investigate novel therapeutic targets in neurodegenerative disease.
• Develop and apply advanced human iPSC-based models and disease-relevant assays to evaluate target biology and therapeutic potential.
• Design, optimize, and implement mechanistic and translational assays that enable target interrogation, in vitro pharmacological characterization, compound profiling, and progression of drug-discovery programs.
• Establish causal relationships between target modulation and disease-relevant mechanisms using genetic, pharmacological, and molecular approaches.
• Support structure-activity relationship (SAR) efforts by generating high-quality in vitro pharmacology data that inform compound optimization, mechanism-of-action studies, and program progression.
• Represent Discovery Biology on cross-functional program teams, presenting experimental results and biological interpretation to support program progression.

Conocimientos

Molecular biology

Cell biology

iPSC models

Target validation

Drug discovery

Educación

Bachelor's + 4+ years

Master's + 2+ years

Degree in neuroscience/biology/molecular biology/cell biology

Descripción del empleo

Bristol Myers Squibb, Cambridge Crossing, MA, is seeking a Senior Associate Scientist - In vitro Biology in Neuroscience Discovery to advance novel targets using human iPSC-based models. You will design disease-relevant assays and collaborate across Discovery Biology to translate biology into therapeutic hypotheses.

The ideal candidate has strong molecular and cellular biology expertise and experience translating biological questions into meaningful therapeutic hypotheses.