Senior Associate Scientist In vitro Biology Neuroscience Discovery

Bristol Myers Squibb; Massachusetts; Presencial; USD 105.000 - 127.000; Jornada completa

Descripción de la vacante

Bristol Myers Squibb, Cambridge Crossing, MA, is seeking a Senior Associate Scientist - In vitro Biology in Neuroscience Discovery to advance novel targets using human iPSC-based models. You will design disease-relevant assays and collaborate across Discovery Biology to translate biology into therapeutic hypotheses.

The ideal candidate has strong molecular and cellular biology expertise and experience translating biological questions into meaningful therapeutic hypotheses.

Formación

• Bachelor's degree with 4+ years of academic and/or industry experience.
• Master's degree with 2+ years of academic and/or industry experience.
• Degree in neuroscience, biology, molecular biology, or related discipline.
• Strong foundation in molecular and cellular biology.
• Experience developing and applying cellular assays for target validation, pharmacological characterization, and/or compound profiling.
• Hands-on experience with human iPSC-derived neural and/or glial models and their application to neurodegenerative disease research.

Responsabilidades

• Design and execute hypothesis-driven studies to investigate novel therapeutic targets in neurodegenerative disease.
• Develop and apply advanced human iPSC-based models and disease-relevant assays to evaluate target biology and therapeutic potential.
• Design, optimize, and implement mechanistic and translational assays that enable target interrogation, in vitro pharmacological characterization, compound profiling, and progression of drug-discovery programs.
• Establish causal relationships between target modulation and disease-relevant mechanisms using genetic, pharmacological, and molecular approaches.
• Support structure-activity relationship (SAR) efforts by generating high-quality in vitro pharmacology data that inform compound optimization, mechanism-of-action studies, and program progression.
• Represent Discovery Biology on cross-functional program teams, presenting experimental results and biological interpretation to support program progression.

Conocimientos

Molecular biology

Cell biology

iPSC models

Target validation

Drug discovery

Educación

Bachelor's + 4+ years

Master's + 2+ years

Degree in neuroscience/biology/molecular biology/cell biology

Descripción del empleo

At Bristol Myers Squibb, our employees often ask, "Who are you working for?"-a question that fuels collaboration, accountability, and urgency in our work. Our purpose-driven culture inspires us to discover, develop, and deliver innovative medicines to prevail over serious diseases. We offer uniquely interesting and meaningful work, opportunities for growth, and a supportive environment that values inclusion, wellbeing, flexibility, and comprehensive benefits. This is work that transforms the lives of patients, and the careers of those who do it.

Senior Associate Scientist - In vitro Biology, Neuroscience Discovery

The Neuroscience TRC is committed to discovering and developing new therapies for patients with neurodegenerative and neuromuscular diseases. Our research combines human disease biology, molecular and cellular neuroscience, and target validation to identify and advance promising therapeutic opportunities.

We are seeking a creative and rigorous scientist to investigate novel therapeutic targets and build confidence in their relevance to neurodegenerative disease. The successful candidate will develop and apply disease-relevant assays and advanced human iPSC-based models to understand how genetic or pharmacologic target modulation influences disease biology.

This role is ideal for a scientist with strong molecular and cellular biology expertise, a passion for understanding disease mechanisms, and experience translating biological questions into meaningful therapeutic hypothesis. The ideal candidate will have experience developing disease-relevant cellular assays and applying advanced human iPSC-based models to investigate target biology. Experience with microglia, neuroimmune biology, or multicellular CNS models is highly desirable.

Position Responsibilities

• Design and execute hypothesis-driven studies to investigate novel therapeutic targets in neurodegenerative disease.
• Develop and apply advanced human iPSC-based models and disease-relevant assays to evaluate target biology and therapeutic potential.
• Design, optimize, and implement mechanistic and translational assays that enable target interrogation, in vitro pharmacological characterization, compound profiling, and progression of drug-discovery programs.
• Establish causal relationships between target modulation and disease-relevant mechanisms using genetic, pharmacological, and molecular approaches.
• Support structure-activity relationship (SAR) efforts by generating high-quality in vitro pharmacology data that inform compound optimization, mechanism-of-action studies, and program progression.
• Represent Discovery Biology on cross-functional program teams, presenting experimental results and biological interpretation to support program progression.

Basic Qualifications

• Bachelor's degree with 4+ years of academic and/or industry experience or
• Master's degree with 2+ years of academic and/or industry experience

Preferred Qualifications

• Degree in neuroscience, biology, molecular biology, cell biology, or a related discipline.
• Strong foundation in molecular and cellular biology, with experience designing and executing experiments to address biological questions.
• Experience developing and applying cellular assays for target validation, pharmacological characterization, and/or compound profiling.
• Hands-on experience with human iPSC-derived neural and/or glial models and their application to neurodegenerative disease research.
• Demonstrated ability to independently drive experiments from conception through data interpretation and clearly present scientific findings within multidisciplinary teams

Additional Preferred Qualifications and Experience

• Strong understanding of neurodegenerative disease biology, including pathways related to mitochondrial function, neuroinflammation, lipid and lysosomal biology, and protein homeostasis.
• Experience developing and applying robust cellular assays for target validation, pharmacological characterization, or compound profiling.
• Experience with disease-relevant cellular models and phenotypic endpoints applicable to neurodegenerative disease.
• Industry experience supporting target validation, in vitro pharmacology, or drug-discovery programs is beneficial.

Compensation Overview:

• Cambridge Crossing: $105,040 - $127,287

The starting pay range(s) listed above is for full-time employees (FTE). You may also be eligible for additional discretionary incentive cash and stock opportunities. We determine starting pay thoughtfully - carefully considering the nature of the role, required skills, work location, schedule and the knowledge and experience you bring. Final compensation is guided by pay equity principles and applicable employment laws. Compensation programs are reviewed on an ongoing basis and may be adjusted over time to reflect evolving market factors