In Vitro Neuroscience Scientist: iPSC Models & Validation

Bristol-Myers Squibb Co; Cambridge (MA); Sur place; USD 105 000 - 127 000; Plein temps

Résumé du poste

Bristol Myers Squibb is seeking a Senior Associate Scientist in vitro biology for neuroscience discovery in Cambridge, MA. You will develop disease-relevant iPSC-based models and advanced cellular assays to understand target biology and disease mechanisms, contributing to translational pharmacology and program progression.

Independent experimentation, cross-functional collaboration, and rigorous data interpretation are essential.

Qualifications

• Bachelor's with 4+ years or Master's with 2+ years in neuroscience, biology, molecular biology, or a related discipline.
• Strong foundation in molecular and cellular biology with experience designing and executing experiments.
• Experience developing cellular assays for target validation and pharmacological profiling.
• Hands-on experience with human iPSC-derived neural and/or glial models.

Responsabilités

• Design and execute hypothesis-driven studies to investigate novel therapeutic targets in neurodegenerative disease.
• Develop and apply advanced human iPSC-based models and disease-relevant assays to evaluate target biology and therapeutic potential.
• Design, optimize, and implement mechanistic and translational assays that enable target interrogation, in vitro pharmacological characterization, compound profiling, and progression of drug-discovery programs.
• Establish causal relationships between target modulation and disease-relevant mechanisms using genetic, pharmacological, and molecular approaches.
• Support structure-activity relationship (SAR) efforts by generating high-quality in vitro pharmacology data that inform compound optimization, mechanism-of-action studies, and program progression.
• Represent Discovery Biology on cross-functional program teams, presenting experimental results and biological interpretation to support program progression.

Connaissances

Molecular biology

Cell biology

Neuroscience

Data interpretation

Experiment design

Formation

Bachelor's or Master's in neuroscience/biology

Outils

iPSC culture

Cell-based assays

Description du poste

Bristol Myers Squibb is seeking a Senior Associate Scientist in vitro biology for neuroscience discovery in Cambridge, MA. You will develop disease-relevant iPSC-based models and advanced cellular assays to understand target biology and disease mechanisms, contributing to translational pharmacology and program progression.

Independent experimentation, cross-functional collaboration, and rigorous data interpretation are essential.