Neuronal Scientist I/II: iPSC & ASO Discovery

Camp4 Therapeutics; Cambridge (MA); On-site; USD 125,000 - 150,000; Full time

Benefits offered by this job

Annual bonus opportunities

Equity incentive opportunities

Job summary

CAMP4 Therapeutics in Cambridge, MA is seeking a Scientist I/II to join our Discovery team and advance CNS programs from target validation to candidate nomination. The role focuses on developing functional and phenotypic assays in human iPSC-derived neurons to support ASO drug discovery.

Ideal candidate has a PhD in neuroscience or related field, 0–3 years post‑doc, and hands‑on experience with MEA, calcium imaging, and high‑content imaging. Collaborative, data‑driven approach required.

Qualifications

• PhD in neuroscience, molecular biology, cell biology, or a related discipline with 0‑3 years of post‑degree experience.
• Hands‑on experience with neuronal functional or phenotypic assays, including MEA, calcium imaging, or high‑content imaging.
• Strong mammalian cell culture skills and experience with human iPSC‑derived neurons.

Responsibilities

• Develop, optimize, and implement functional and phenotypic assays in human iPSC‑derived neurons, including MEA, calcium imaging, and high‑content imaging.
• Establish disease‑relevant neuronal phenotypes and evaluate responses to candidate ASOs.
• Design experiments to support target validation and candidate selection across CNS programs.
• Develop cellular and biochemical assays to assess target engagement and downstream effects of ASOs.
• Analyze and communicate results to project teams and collaborators.
• Collaborate with cross‑functional scientists to integrate assay data with molecular and pharmacological data.
• Maintain detailed records for regulatory documentation of candidate ASOs.

Skills

MEA

Calcium imaging

High-content imaging

Neuronal assays

Quantitative analysis

Education

PhD in neuroscience or related discipline

Tools

Immunofluorescence

Microscopy

Cell culture

iPSC-derived neurons

Job description

CAMP4 Therapeutics in Cambridge, MA is seeking a Scientist I/II to join our Discovery team and advance CNS programs from target validation to candidate nomination. The role focuses on developing functional and phenotypic assays in human iPSC-derived neurons to support ASO drug discovery.

Ideal candidate has a PhD in neuroscience or related field, 0–3 years post‑doc, and hands‑on experience with MEA, calcium imaging, and high‑content imaging. Collaborative, data‑driven approach required.