Neuroscience Exploratory Scientist: Disease Pathways

Bristol-Myers Squibb Co; Cambridge (MA); On-site; USD 105,000 - 127,000; Full time

Benefits offered by this job

Flexible Time Off

11 paid holidays

Paid vacation

Job summary

Bristol Myers Squibb is seeking a Sr Associate Scientist in Cambridge to join the Neuroscience Exploratory Biology group. This role focuses on characterizing disease-relevant biology using primary and iPSC-derived neuronal and glial systems, supporting target validation and mechanism-of-action studies to advance early-stage neuroscience programs.

You will design and execute experiments, apply immunofluorescence and high-content imaging, perform qPCR, JESS, ELISA and MEA, and collaborate with

Qualifications

• Bachelor's degree in Biology, Neuroscience, Pharmacology, Biochemistry, or a related field plus 4+ years of relevant experience
• Or a Master's degree plus 2+ years of relevant experience
• Hands-on academic, biotechnology, or pharmaceutical experience, including mammalian cell culture
• Experience in assay development, target validation, genome editing, genetic perturbation, and mechanism-of-action studies
• Proficiency in qPCR, JESS, ELISA, immunofluorescence, microscopy, high-content imaging and analysis
• Direct experience with primary neuronal cultures, iPSC-derived neurons and glia, and other neuroscience-relevant in vitro systems strongly preferred
• Ability to independently design, execute, troubleshoot, document, analyze, and present reproducible experiments
• Data analysis or visualization experience desirable
• Strong organizational and communication skills; able to work independently and cross-functionally in a fast-paced environment
• Curiosity, initiative, adaptability, attention to detail, problem-solving, and commitment to scientific rigor, safety, and data quality
• Strong foundational neuroscience knowledge preferred

Responsibilities

• Design, execute, and troubleshoot experiments to explore neurobiological mechanisms underlying disease-relevant pathways
• Culture and maintain primary neuronal cultures, iPSC-derived neurons and glia, and other neuroscience-relevant in vitro systems
• Perform target validation studies, including genome editing and genetic perturbation approaches
• Conduct mechanism-of-action studies to characterize compound or genetic effects on neuronal and glial biology
• Apply immunofluorescence, microscopy, and high-content imaging/analysis to assess cellular phenotypes
• Perform qPCR, JESS, ELISA and MEA to support molecular, biochemical and functional characterization
• Analyze, document, and present data with rigor and reproducibility; contribute to experimental design discussions
• Collaborate cross-functionally with computational biology, translational, and drug discovery teams
• Stay current with neuroscience literature and contribute scientific insight to project strategy

Skills

Neuroscience expertise

Cell culture

Genome editing

qPCR/ELISA/immunofluorescence

Data analysis

Education

Bachelor's degree in Biology/Neuroscience/Related

Master's degree in relevant field

Tools

qPCR

JESS

ELISA

MEA

Job description

Bristol Myers Squibb is seeking a Sr Associate Scientist in Cambridge to join the Neuroscience Exploratory Biology group. This role focuses on characterizing disease-relevant biology using primary and iPSC-derived neuronal and glial systems, supporting target validation and mechanism-of-action studies to advance early-stage neuroscience programs.

You will design and execute experiments, apply immunofluorescence and high-content imaging, perform qPCR, JESS, ELISA and MEA, and collaborate with