mRNA process development scientist

Serova; San Francisco (CA); On-site; USD 150,000 - 190,000; Full time

Job summary

Serova, a San Francisco biotech company, seeks a hands-on RNA scientist to make and QC patient-specific mRNA and LNP vaccines. You will build fast, reliable pipelines for production and QC, enabling rapid scaling as we advance a GMP facility in collaboration with Twist.

You will contribute to process development, transfer to GMP, and cross-functional collaboration with internal teams to ensure quality and patient safety.

Qualifications

• A PhD, or 3+ years in industry, working on RNA or nucleic acid therapeutics.
• Hands-on with IVT, purification, LNP formulation and QC
• Based in the San Francisco Bay Area, or willing to relocate
• Authorized to work in the US, or a realistic path to get there

Responsibilities

• Make and QC our mRNA and LNPs.
• Build the process and QC pipelines to make each vaccine quickly and reliably.
• Help transfer the process into the GMP facility we are building with Twist.

Skills

RNA purification

mRNA & LNP QC

Python scripting

Process optimization

Education

PhD in RNA therapeutics

Tools

IVT

LNP formulation

NGS

LC-MS

Job description

About Serova

Serova builds personalized cancer vaccines. Each vaccine is made for the individual patient from their own samples and given in partnership with their treating physician. Every batch we make is for one patient, and we're building a GMP manufacturing facility with Twist to make them.

The role

Every batch we make is for one patient. You'll make and QC our mRNA and LNPs, and build the process and QC pipelines that let us make each vaccine quickly and reliably. You'll also help carry that process into the GMP facility we're building with Twist.

Who you are

• A hands-on RNA scientist who has produced, purified and QC'd mRNA and LNPs at the bench
• You enjoy making the pipeline faster
• High agency, friendly and low ego

Requirements

• A PhD, or 3+ years in industry, working on RNA or nucleic acid therapeutics
• Hands-on with IVT, purification, LNP formulation and QC
• Based in the San Francisco Bay Area, or willing to relocate
• Authorized to work in the US, or a realistic path to get there

What will make you stand out

• High-throughput QC: you've built QC pipelines for RNA and DNA using NGS, capillary electrophoresis or LC-MS
• RNA-LNP production at a biotechnology company
• RNA chemistry: modifications, capping, conjugation
• Liquid handling and automation
• You write Python for your own analysis
• Tech transfer into GMP, or work with CDMOs

Details

• Location: San Francisco
• Type: Full-time