Microfluidics Consumable Engineer for RNA Manufacturing

System One, Inc.; Boston (MA); On-site; USD 86,000 - 123,000; Full time

Job summary

System One is seeking a Microfluidics/Consumable Engineer in Boston, MA for a contract-to-hire onsite role. You will own the engineering of the consumables for the manufacturing platform and manage the end-to-end flow path across DNA template preparation, purification, and encapsulation.

You should have MS/PhD in engineering with microfluidics, 6+ years of hands-on experience, and expertise in low-Reynolds-number flow, materials selection, and fabrication methods.

Qualifications

• MS or PhD in mechanical, chemical, or biomedical engineering, or a related discipline with a microfluidics specialization.
• At least six years of experience designing and building microfluidic or milli-fluidic devices that have gone into real use.
• Strong understanding of low-Reynolds-number flow, mixing, pressure drop, residence time, and microfluidic nanoparticle formation, including how mixing parameters impact particle size, polydispersity, and encapsulation efficiency.
• Hands-on fabrication experience across at least two of the following: injection molding, hot embossing, laser micromachining, CNC micro-milling, film lamination, laser or ultrasonic welding, and pressure-sensitive adhesive bonding.
• Experience in fluidic network design and/or CFD applied to real design decisions.

Responsibilities

• Own the engineering of the consumables for the manufacturing platform.
• Manage the flow path carrying every unit operation of the end-to-end process including DNA template preparation/amplification, purification/filtration, and encapsulation.
• Design channel geometry and hydrodynamics, mixing elements, valve and actuator placement, in-line sensing locations, and fluid-path interfaces to various subsystems.
• Select materials and joining methods compatible with sterilization under ISO 11137.
• Conduct bench de-risking of cartridge unit operations, fabricate the initial cartridge lot, and verify cartridges against set acceptance criteria.

Skills

Microfluidics design

CFD

Prototyping

Materials selection

Education

MS/PhD in mechanical/chemical/biomedical engineering with microfluidics

Tools

Injection molding

Laser micromachining

Job description

System One is seeking a Microfluidics/Consumable Engineer in Boston, MA for a contract-to-hire onsite role. You will own the engineering of the consumables for the manufacturing platform and manage the end-to-end flow path across DNA template preparation, purification, and encapsulation.

You should have MS/PhD in engineering with microfluidics, 6+ years of hands-on experience, and expertise in low-Reynolds-number flow, materials selection, and fabrication methods.