Lead RNA Purification & Analytics Scientist (Onsite — Boston)

System One, Inc.; Boston (MA); On-site; USD 96,000 - 136,000; Full time

Job summary

System One, Inc. in Boston is seeking a Purification & Analytics Scientist to lead RNA purification and define analytical strategies for batch release. The role is onsite in Boston, MA, with a contract-to-hire arrangement and standard business hours.

The candidate will oversee purification operations, develop quality attributes, and implement analytical targets aligned with ICH guidelines, ensuring robust in-process and release testing.

Qualifications

• PhD or MS in analytical chemistry, biochemistry, or bioprocess engineering.
• Minimum of five years of experience in biologics or nucleic-acid purification and analytical development.
• Ability to cover both purification process expertise and analytical expertise; candidates strong in only one area will leave a gap.

Responsibilities

• Lead specialist in RNA purification and analytical strategy to determine batch release.
• Manage purification unit operations: tangential flow filtration, membrane or chromatographic purification, including double-stranded RNA removal below 1% w/w and residual DNA below 10 ng/mg.
• Develop and maintain the product quality attribute list per modality, mapped to quality-control measurement domains.
• Define analytical target profiles for each attribute according to ICH Q2(R2) and Q14, including accuracy, precision, range, and specificity.
• Rank and prioritize in-line, at-line, and off-line analytical technologies against established profiles with documented criteria.

Skills

RNA purification

Analytical strategy

Leadership

Education

PhD or MS in Analytical Chemistry/Biochemistry/Bioprocess Eng

Job description

System One, Inc. in Boston is seeking a Purification & Analytics Scientist to lead RNA purification and define analytical strategies for batch release. The role is onsite in Boston, MA, with a contract-to-hire arrangement and standard business hours.

The candidate will oversee purification operations, develop quality attributes, and implement analytical targets aligned with ICH guidelines, ensuring robust in-process and release testing.