LNP Analytics Associate Scientist - In Vivo Gene Editing

stylusmedicine; Cambridge (MA); Presencial; USD 105.000 - 115.000; Jornada completa

Descripción de la vacante

Stylus Medicine in Cambridge, MA, is seeking an Associate Scientist to support analytical development of lipid nanoparticle (LNP) characterizations for in vivo genome engineering. You will develop and apply analytical methods, support delivery teams, and help advance gene editing modalities.

The role requires collaboration with cross-functional teams, SOP development, and strong documentation. A biochemistry/engineering background with 2–4 years of LNP experience is preferred.

Formación

• Undergraduate or master's degree in biochemistry, chemical engineering, materials science, or a related field.
• 2-4 years of industry/academic experience focusing on LNP characterization.
• Prior experience with characterization of targeted nanoparticles is strongly preferred.
• Strong foundation in lipid chemistry, formulation development, and analytical techniques.
• Familiarity with gene editing modalities or nucleic acid delivery (e.g. CRISPR/Cas, base editing, mRNA, DNA) is a plus.
• Demonstrated ability to thrive in a fast-paced, innovative environment.
• Strong communication skills, with the ability to collaborate effectively with cross-functional teams to meet project deliverables and timelines.
• Demonstrated ability to work independently, multitask effectively, and maintain strong written documentation.

Responsabilidades

• Leverage expertise in lipid chemistry, LNP formulation and analytical characterization to advance novel gene editing modalities across different stages of drug development
• Develop methods such as BLA, CBQCA, DLS, , UPLC, HPLC-CAD, IP-RP HPLC, LC-MS/MS, CGE, BLI/SPR, ELISA and ddPCR/qPCR to screen and support optimal LNP formulations for in vitro and in vivo applications
• Author standard operating procedures, study plans, reports, and present findings to project teams and leadership
• Work in close collaboration with the cross-functional teams to support in vitro and in vivo experiments assessing biodistribution, safety and efficacy of LNP formulations
• Foster external collaborations and stay abreast of emerging trends and innovations in LNP technology, proposing new approaches to enhance the company's delivery platforms, as appropriate

Conocimientos

Lipid chemistry

Formulation development

Analytical techniques

CRISPR/Cas knowledge

Nucleic acid delivery

Cross-functional collaboration

Independent work

Educación

Bachelor's or Master's in Biochemistry / Chemical Engineering / Materials Science

Herramientas

DLS

UPLC

HPLC-CAD

LC-MS/MS

ddPCR/qPCR

ELISA

BLI/SPR

CBQCA

BLA

Descripción del empleo

Stylus Medicine in Cambridge, MA, is seeking an Associate Scientist to support analytical development of lipid nanoparticle (LNP) characterizations for in vivo genome engineering. You will develop and apply analytical methods, support delivery teams, and help advance gene editing modalities.

The role requires collaboration with cross-functional teams, SOP development, and strong documentation. A biochemistry/engineering background with 2–4 years of LNP experience is preferred.