Associate Scientist, LNP Analytics

Stylus Medicine, Inc.; Cambridge (MA); Presencial; USD 90.000 - 130.000; Jornada completa

Descripción de la vacante

Stylus Medicine, Inc. is seeking an Associate Scientist to join our analytical development team, focusing on LNP characterization for in vivo genome delivery.

You will drive development of analytical techniques and provide support to the delivery team, reporting to the Principal Scientist, LNP Analytics. You will collaborate with cross-functional teams on in vitro and in vivo studies, contribute to SOPs and study plans, and help advance transformative in vivo genetic medicines from discovery

Formación

• Undergraduate or master's degree in biochemistry, chemical engineering, materials science, or a related field.
• 2–4 years of industry/academic experience focusing on LNP characterization.
• Prior experience with characterization of targeted nanoparticles is strongly preferred.
• Strong foundation in lipid chemistry, formulation development, and analytical techniques.
• Familiarity with gene editing modalities or nucleic acid delivery (e.g. CRISPR/Cas, base editing, mRNA, DNA) is a plus.
• Demonstrated ability to thrive in a fast-paced, innovative environment.
• Strong communication skills, with the ability to collaborate effectively with cross-functional teams to meet project deliverables and timelines.

Responsabilidades

• Leverage lipid chemistry, LNP formulation and analytics to advance gene editing modalities.
• Develop methods such as BLA, CBQCA, DLS, UPLC, HPLC-CAD, LC-MS/MS, ELISA and ddPCR/qPCR.
• Author SOPs, study plans, reports, and present findings to teams and leadership.
• Collaborate with cross-functional teams for in vitro and in vivo experiments on biodistribution, safety and efficacy.
• Foster external collaborations and stay abreast of LNP trends, proposing new approaches.

Conocimientos

LNP characterization

Analytical methods development

Strong communication

Independent multitasking

Educación

Undergraduate or master's degree in biochemistry, chemical engineering, materials science, or related field

Herramientas

BLA

CBQCA

DLS

UPLC

HPLC-CAD

IP-RP HPLC

LC-MS/MS

CGE

BLI/SPR

ELISA

ddPCR/qPCR

Descripción del empleo

Stylus Medicine is seeking an intellectually curious and collaborative Associate Scientist to join our analytical development team and aid in the development of characterization techniques for lipid nanoparticles (LNPs) to be used for in vivo delivery of genome engineering material. This role will be responsible for both providing analytical support to the delivery team as well as driving the development of novel analytical techniques. Reporting to the Principal Scientist, LNP Analytics, this individual will play an integral role in advancing transformative in vivo genetic medicines.

Key Responsibilities & Accountabilities:

Leverage expertise in lipid chemistry, LNP formulation and analytical characterization to advance novel gene editing modalities across different stages of drug development

Develop methods such as BLA, CBQCA, DLS, , UPLC, HPLC-CAD, IP-RP HPLC, LC-MS/MS, CGE, BLI/SPR, ELISA and ddPCR/qPCR to screen and support optimal LNP formulations for in vitro and in vivo applications

Author standard operating procedures, study plans, reports, and present findings to project teams and leadership

Work in close collaboration with the cross-functional teams to support in vitro and in vivo experiments assessing biodistribution, safety and efficacy of LNP formulations

Foster external collaborations and stay abreast of emerging trends and innovations in LNP technology, proposing new approaches to enhance the company’s delivery platforms, as appropriate

Qualifications & Skills:

Undergraduate or master’s degree in biochemistry, chemical engineering, materials science, or a related field

2-4 years of industry/academic experience focusing on LNP characterization

Prior experience with characterization of targeted nanoparticles is strongly preferred

Strong foundation in lipid chemistry, formulation development, and analytical techniques

Familiarity with gene editing modalities or nucleic acid delivery (e.g. CRISPR/Cas, base editing, mRNA, DNA) is a plus

Demonstrated ability to thrive in a fast-paced, innovative environment

Strong communication skills, with the ability to collaborate effectively with cross-functional teams to meet project deliverables and timelines

Demonstrated ability to work independently, multitask effectively, and maintain strong written documentation

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