Lead TCR Optimization Scientist (Therapeutics)
BioSpace
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Benefits offered by this job
Job summary
Moderna is seeking a Principal Scientist to lead TCR optimization workflows for next‑generation therapeutics in a hands‑on lab setting. You will build scalable experimental platforms to improve affinity, developability, stability, and functional potency, while guiding cross‑functional teams across discovery and translational science.
You will partner with computational biology, AI/ML, and translational groups to inform iterative optimization decisions and generate high‑quality, decision‑ready
Qualifications
- PhD in immunology or related field with 5+ years post‑PhD in TCR engineering or related therapeutic discovery discipline.
Responsibilities
- Build and optimize scalable TCR optimization workflows.
- Establish end-to-end pipelines linking design, screening, and lead selection.
- Lead multi-parameter optimization campaigns balancing affinity, specificity, and developability.
- Collaborate with AI/ML, NGS, and external partners for data‑driven decisions.
- Communicate strategy and results to cross‑functional teams.
Skills
Education
Tools
Job description
Moderna is seeking a Principal Scientist to lead TCR optimization workflows for next‑generation therapeutics in a hands‑on lab setting. You will build scalable experimental platforms to improve affinity, developability, stability, and functional potency, while guiding cross‑functional teams across discovery and translational science.
You will partner with computational biology, AI/ML, and translational groups to inform iterative optimization decisions and generate high‑quality, decision‑ready
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