Senior Scientist, Antibody Discovery & Engineering

Moderna Therapeutics

Cambridge (MA)

On-site

USD 142,500 - 256,500

Full time

14 days+

Application generator

Don’t send a generic resume — generate a resume and cover letter tailored to this exact role.

Get past ATS filters

Benefits offered by this job

Healthcare benefits

Well‑being programs

Generous paid time off

Job summary

Moderna Therapeutics is seeking a Principal Scientist to lead integrated antibody discovery and engineering campaigns across oncology and autoimmune programs. You will oversee immunization design, B cell discovery, display‑based engineering, sequencing, and lead optimization, partnering with antigen design, structural and computational biology groups to advance programs.

The role requires a PhD with 5+ years in antibody discovery/engineering, hands‑on experience across diverse formats,

Qualifications

PhD in immunology, molecular biology, biochemistry, protein engineering, cancer biology, or related discipline with 5+ years post‑PhD industry experience in antibody discovery/engineering.
Independently leads therapeutic antibody discovery campaigns from concept through lead identification, optimization, or nomination.
Deep technical expertise in antibody biology, structure/function, discovery platforms, and optimization.

Responsibilities

Lead integrated antibody discovery and engineering campaigns from early concept through lead identification, optimization, and nomination.
Oversee immunizations, B cell screening, display campaigns, affinity maturation, humanization, and format conversions.
Characterize antibodies across therapeutic formats and assess developability and mechanism of action.
Partner with cross‑functional teams to move programs from concept to actionable leads.
Analyze data and manage outsourced CRO workflows; mentor junior scientists.