Lead Computational Protein Design for TCRs & Antibodies

Moderna Therapeutics; Cambridge (MA); On-site; USD 180,000 - 240,000; Full time

Job summary

Moderna Therapeutics in Cambridge, MA is seeking a Principal Scientist to lead computational protein design across therapeutic research, focusing on TCRs and antibodies and contributing to broader design efforts. The role requires deep expertise in protein structure, de novo binder design, molecular recognition, and state-of-the-art computational design workflows.

You will partner with structural biology, immunology, translational science, and program teams to advance platform innovation and

Qualifications

• Experience leading computational protein design campaigns for therapeutics.
• Focus on de novo binder design for TCRs and antibodies.
• Ability to build integrated computational-to-experimental design platforms.

Responsibilities

• Lead computational protein design campaigns for TCRs and antibodies.
• Develop binder optimization for affinity, specificity, stability, and developability.
• Build an integrated design platform linking generative design, docking, interface scoring, and sequencing.
• Collaborate with cross-functional teams to translate model outputs into experimental data.

Skills

Computational design

TCR design

Antibody design

Molecular modeling

Job description

Moderna Therapeutics in Cambridge, MA is seeking a Principal Scientist to lead computational protein design across therapeutic research, focusing on TCRs and antibodies and contributing to broader design efforts. The role requires deep expertise in protein structure, de novo binder design, molecular recognition, and state-of-the-art computational design workflows.

You will partner with structural biology, immunology, translational science, and program teams to advance platform innovation and