TCR Optimization Lead Scientist

RXinsider LTD.

Cambridge (MA)

On-site

USD 143,000 - 257,000

Full time

14 days+

Application generator

Turn this role into an interview — a resume and cover letter built around what this employer wants.

Get past ATS filters

Benefits offered by this job

Competitive healthcare

Well‑being resources

Generous time off

Location‑specific perks

Job summary

Moderna seeks a Principal Scientist to build and optimize TCR optimization workflows for next-generation TCR-based therapeutics. You will lead scalable experimental platforms to improve affinity, stability, developability, and functional potency, collaborating with cross‑functional teams across AI/ML, computational biology, and translational science.

The role requires deep expertise in display‑based protein engineering, TCR biology, and multi‑parameter data integration to advance candidates

Qualifications

PhD in immunology, protein engineering, molecular biology, biochemistry, biophysics, cell biology, or related disciplines.
At least 5 years of post‑PhD experience in TCR engineering, protein engineering, directed evolution, display‑based screening, or related therapeutic discovery.
Experience executing TCR or TCR‑mimetic optimization workflows linking binding, stability, expression, developability, and potency.
Hands‑on experience with display technologies and library design for affinity maturation and developability optimization.

Responsibilities

Build and optimize scalable TCR optimization workflows.
Establish end‑to‑end pipelines linking library design to lead selection.
Design rational TCR libraries informed by structure and biology.
Lead multi‑parameter optimization campaigns balancing affinity, specificity, stability, and developability.
Collaborate with AI/ML, NGS, and cross‑functional teams to drive data integration.