Lead Scientist, Targeted CNS Delivery & Cell Pharmacology

Stealth Co; Cambridge (MA); Presencial; USD 120.000 - 180.000; Jornada completa

Ventajas ofrecidas por este puesto de trabajo

Competitive compensation

Small-team environment

Growth opportunities

Descripción de la vacante

Stealth Co in Cambridge, MA seeks a scientifically agile scientist to drive screening and characterization of candidate molecules from our targeted delivery platform, designed to reach a range of targets and tissues. This laboratory-based role will be responsible for designing, executing, and interpreting in vitro and ex vivo experiments that rank candidate molecules and support scientific decision-making.

The successful candidate will be mechanistically minded, able to connect experimental

Formación

• Hands-on experience measuring transport across tight-junction barrier models in vitro/in vivo.
• Understanding of receptor-mediated transcytosis, uptake, and intracellular trafficking.
• Proven tissue culture experience with human cell lines and primary human cells.
• Track record building novel cell-based assays advancing drug discovery.
• Experience with nucleic acid assays (qPCR, RNA-seq) and protein assays (flow cytometry, ELISA, Western blot, imaging).
• Scientific independence: owning a project and shaping its research plan quickly.

Responsabilidades

• Develop and execute new cell-based assays to screen constructs against multiple targets, including transport across in vitro barrier models (transwell systems, primary and iPSC-derived cells, co-culture).
• Develop, optimize, and perform cell-based assays to evaluate pharmacology of binders and AOC variants on phenotypic readouts (receptor binding, trafficking, transcytosis).
• Culture and differentiate multiple cell lines and primary human cells using established and custom protocols.
• Lead candidate optimization within an integrated cross-functional team using in vitro and in vivo models to advance the program toward key decisions.
• Translate and develop RNA-based and protein-based assays to support in vivo pharmacology studies.
• Manage CROs for reagent production, optimization, and scale-up to support in vitro and in vivo studies.
• Mentor associates, maintain detailed records, present findings in team meetings, ensure lab safety and quality standards.

Educación

PhD in Cell Biology, Neuroscience, Molecular Biology, Biochemistry, or related field

BS/MS with 6+ years and independent program ownership

Herramientas

Transwell barrier models

iPSC-derived cells

Co-culture systems

Descripción del empleo

Stealth Co in Cambridge, MA seeks a scientifically agile scientist to drive screening and characterization of candidate molecules from our targeted delivery platform, designed to reach a range of targets and tissues. This laboratory-based role will be responsible for designing, executing, and interpreting in vitro and ex vivo experiments that rank candidate molecules and support scientific decision-making.

The successful candidate will be mechanistically minded, able to connect experimental