Scientist - Neurology

BPGbio, Inc.; Waltham (MA); On-site; USD 120,000 - 170,000; Full time

Job summary

BPGbio, Inc. in Waltham, MA seeks a Scientist in Neurology to join the Discovery & Translational Biology Group. You will leverage molecular and cellular biology, biochemistry and protein sciences to advance target validation and drug discovery within an integrated team.

The role emphasizes independent development of lab assays, data analysis, and collaboration with cross-functional groups to support biological characterization of novel targets and progression of drug candidates.

Qualifications

• PhD required with 1–5 years of postdoctoral experience.
• Strong grasp of neural physiology and systems biology is desirable.
• Excellent oral and written communication, manuscript preparation.
• Experience developing and presenting comprehensive reports.

Responsibilities

• Perform assays to support target validation and drug discovery.
• Characterize novel drug targets and their biology.
• Develop and implement assays for potency, target engagement and MOA.
• Maintain records, organize data, and present reports.
• Coordinate with internal groups and external partners/CROs.
• Manage project timelines and workflows.
• Mentor junior team members.
• Other duties as assigned.

Skills

Neurobiology understanding

Cellular metabolism

Neurological disease models

Critical thinking

Creative problem-solving

Education

PhD in neuroscience or biochemistry

Job description

The Scientist in Neurology is a highly skilled and motivated individual who will be part of an integrated research team within the Discovery & Translational Biology Group. The Scientist will have profound research experience in molecular and cell biology, biochemistry and/or protein sciences applied in the context of drug discovery and biological characterization of novel targets. The Scientist will develop and implement scientific research in the laboratory as well as collaborate with cross-functional groups to support target assessment/validation and drug discovery activities.

ESSENTIAL DUTIES AND RESPONSIBILITIES:

• Perform the full spectrum of laboratory activities and independently develop, troubleshoot, and optimize cell-based and biochemical assays in support of target validation, drug discovery, and development efforts
• Independently identify, develop, and implement methods for the characterization of novel drug targets and their biology.
• Independently develop proposals and implement assays for assessment of potency, target engagement, and mechanism of action of novel compounds using multiple techniques (e.g., recombinant DNA techniques, RNA purification, Western, PCR, RT-qPCR, protein extraction/purification, IP, flow cytometry, plate-based endpoints).
• Maintain laboratory records and notebook, organize and compile data, and write and present comprehensive reports on results.
• Facilitate interactions with internal groups and external partners/CROs relevant to experimental projects.
• Handle laboratory workflows and participate in project/timeline management.
• Mentor and assist junior team members.
• Other duties as assigned

REQUIREMENTS:

• Requires a Ph.D. in neuroscience, biochemistry, or a related field with 1-5 years of postdoctoral experience.
• Strong understanding of neurobiology, cellular metabolism, and neurological disease models as well as critical thinking and creative problem-solving abilities.
• Extensive knowledge of neural physiology and systems biology is desirable.
• Solid scientific training/productivity as identified through high-impact publications demonstrating creative thinking as well as innovative technical approaches.
• Excellent oral and written communication skills and a proven ability to prepare manuscripts for presentation and publication is required.