RNA Drug Discovery Scientist — Biophysics & SPR

Stealth Startup; Boston (MA); On-site; USD 90,000 - 130,000; Full time

Benefits offered by this job

Collaborative, science-driven culture

Direct impact on project strategy and/

Job summary

Stealth Startup in Cambridge, MA is seeking a hands-on Scientist to lead biophysical and biochemical assay development for novel small molecule discovery. You will report to the Director of Biochemistry and collaborate with a small team on site in Cambridge.

The role emphasizes independent development and execution of rigorous experiments, combining strong technical skills with clear communication across disciplines.

Qualifications

• MS + 4 years industry experience or PhD in Biophysics, Biochemistry, Biology, Chemistry, or other relevant field
• 2-4 years of industry experience in small-molecule drug discovery
• Hands-on expertise with biophysical methodologies for RNA-small molecule interactions (SPR, BLI, TR-FRET)
• Experience translating mechanistic/structural insights into hit-to-lead strategies
• Proven ability to work independently and drive projects with minimal supervision
• Excellent communication and collaborative mindset
• Authorized to work in US

Responsibilities

• Own SPR workflows: establish, data generation, instrument maintenance, troubleshooting, external collaborations
• Propose and establish additional biophysical/biochemical assays to advance RNA-targeting discovery
• Document and maintain SOPs with timely electronic lab notebook entries
• Oversee CRO partners across assay design, execution, and troubleshooting

Skills

Independent worker

Strong communication

Collaborative mindset

Biophysical assay development

Education

MS or PhD in Biophysics/Biochemistry/Biology/Chemistry

Tools

SPR

BLI

TR-FRET

Job description

Stealth Startup in Cambridge, MA is seeking a hands-on Scientist to lead biophysical and biochemical assay development for novel small molecule discovery. You will report to the Director of Biochemistry and collaborate with a small team on site in Cambridge.

The role emphasizes independent development and execution of rigorous experiments, combining strong technical skills with clear communication across disciplines.