Lead Scientist, In Vivo Genome Editing Therapeutics

stjude; Memphis (TN); On-site; USD 104,000 - 238,000; Full time

Benefits offered by this job

St. Jude Benefits

Job summary

St. Jude Children’s Research Hospital invites applications for a Lead Scientist or Senior Scientist in the Tsai Lab to advance an in vivo base editing platform. The role focuses on developing genome editing drug products, IND-enabling studies, and translating novel edits toward patient therapies.

You will lead a multi-disciplinary team and drive delivery strategies for HSC-targeted editors, with opportunities for clinical translation within DRIVE and ARPA-H.

Qualifications

• PhD in relevant scientific area is required, such as genomics, molecular and cell biology.
• Expertise in genome editing, genomics, next-generation sequencing.
• Excellent communication, organizational, and presentation skills.
• Four or more years of hands-on research with CRISPR genome editors and NGS library prep.

Responsibilities

• Coordinate a team of scientists working to develop a novel gene editing platform.
• Accelerate lead-target discovery, genotoxicity characterization, and cargo optimization.
• Non-clinical pharmacology studies of an HSC-targeted lipid nanoparticle.
• Continuously assess and manage project technical and drug development risks.
• Analyze experimental outcomes and develop high-quality summaries.
• Summarize results and present updates to the broader DRIVE and ARPA-H teams.
• Draft manuscripts and figures for publication in high-impact journals.

Skills

Genome editing

Genomics

NGS

CRISPR

Education

PhD in genomics / molecular & cell biology

Job description

St. Jude Children’s Research Hospital invites applications for a Lead Scientist or Senior Scientist in the Tsai Lab to advance an in vivo base editing platform. The role focuses on developing genome editing drug products, IND-enabling studies, and translating novel edits toward patient therapies.

You will lead a multi-disciplinary team and drive delivery strategies for HSC-targeted editors, with opportunities for clinical translation within DRIVE and ARPA-H.