Lead or Senior Scientist - Genome Editing, Genomics, Biotechnology (Shengdar Q. Tsai Lab)

stjude; Memphis (TN); On-site; USD 104,000 - 238,000; Full time

Benefits offered by this job

St. Jude Benefits

Job summary

St. Jude Children’s Research Hospital invites applications for a Lead Scientist or Senior Scientist in the Tsai Lab to advance an in vivo base editing platform. The role focuses on developing genome editing drug products, IND-enabling studies, and translating novel edits toward patient therapies.

You will lead a multi-disciplinary team and drive delivery strategies for HSC-targeted editors, with opportunities for clinical translation within DRIVE and ARPA-H.

Qualifications

• PhD in relevant scientific area is required, such as genomics, molecular and cell biology.
• Expertise in genome editing, genomics, next-generation sequencing.
• Excellent communication, organizational, and presentation skills.
• Four or more years of hands-on research with CRISPR genome editors and NGS library prep.

Responsibilities

• Coordinate a team of scientists working to develop a novel gene editing platform.
• Accelerate lead-target discovery, genotoxicity characterization, and cargo optimization.
• Non-clinical pharmacology studies of an HSC-targeted lipid nanoparticle.
• Continuously assess and manage project technical and drug development risks.
• Analyze experimental outcomes and develop high-quality summaries.
• Summarize results and present updates to the broader DRIVE and ARPA-H teams.
• Draft manuscripts and figures for publication in high-impact journals.

Skills

Genome editing

Genomics

NGS

CRISPR

Education

PhD in genomics / molecular & cell biology

Job description

A Lead or Senior Scientist opportunity with the Tsai Lab to develop a therapeutic platform for in vivo base editing treatments and drug products to treat patients with bone marrow failure disorders at St. Jude.

Help us build an individualized therapeutic base editing platform to treat St. Jude patients with rare bone marrow failure disorders by correcting their disease-causing mutations in their hematopoietic stem cells in vivo. Dr. Tsai leads the recently launched DRIVE project ( D elivering Rare-disease In vivo Editors), funding a multi-institutional, public-private partnership to develop in vivo base editors for treatment of bone marrow failure disorders.

Bring your expertise in genome editing drug development to a Lead Scientist role in the Tsai Lab , where you will help advance genome editing technologies toward individualized treatments for pediatric patients. Our goal is to develop in vivo base editing drug products, complete IND-enabling studies, and open clinical trials in the next 3 years.

About the job opportunity. We are seeking an outstanding and highly motivated Lead Scientist or Senior Scientist to help lead efforts to develop personalized genome editing treatments. We care deeply about the success of our scientists, and this is a unique opportunity to help lead development of an in vivo gene therapeutic gene editing platform and drug products at St. Jude, with substantial room for career growth and advancement.

Overview of our lab. The Tsai lab is a highly collaborative, creative, and motivated group of scientists at St. Jude Children's Research Hospital. Our research centers on development of state-of-the-art genomic methods for understanding the global activities of genome editors, protein engineering to improve capabilities for precise editing, and translation to autologous genome edited hematopoietic stem cell therapies. Dr. Tsai also co-leads the PARADIGM ( P artnership to A dvance D evelopment of I ndividualized G enomic M edicines) blue sky project.

You would have opportunities to lead an exciting and fast-paced drug development effort:

• Design and develop in vivo base editing drug products to treat St. Jude patients with bone marrow failure disorders.
• Characterize the genotoxicity of candidate drug products using state-of-the art genomic assays such as CHANGE-seq-BE and CHANCE-seq, including variant-aware analysis.
• Optimize potency and specificity of a HSC-targeted lipid nanoparticle gene editing approach.
• Co-lead a multi-disciplinary team to test a new streamlined platform approach for in vivo genome editing medicines.

You would learn valuable skills that include:

• Genome engineering, high-throughput genomics, laboratory automation, IND-enabling studies for genome editing drug development.

Project-dependent responsibilities would include:

• Coordinate a team of scientists working to develop a novel gene editing platform.
• Accelerate lead-target discovery, genotoxicity characterization, and cargo optimization.
• Non-clinical pharmacology studies of an HSC-targeted lipid nanoparticle.
• Continuously assess and manage project technical and drug development risks.
• Analyze experimental outcomes and develop high-quality summaries.
• Summarize results and present updates to the broader DRIVE and ARPA-H teams.
• Draft manuscripts and figures for publication in high-impact journals.

Minimum Education and/or Training:

• PhD in relevant scientific area is required, such as genomics, molecular and cell biology.
• Expertise in genome editing, genomics, next-generation sequencing.
• Excellent communication, organizational, and presentation skills.
• Four or more years of hands-on research laboratory experience working with CRISPR genome editors and NGS library preparation.

Lead Scientist Minimum Experience:

• Twelve (12) years of relevant work experience is required with a Bachelor's degree
• Ten (10) years of relevant experience is required with a Master's degree
• Seven (7) years of relevant work experience is required with a PhD

Salary Range: $125,840.00/yr. - $238,160.00/yr.

Senior Scientist Minimum Experience:

• Ten (10) years relevant work experience is required
• Eight (8) years of relevant work experience is required with a Master's degree
• Five (5) years of relevant work experience is required with a PhD

Salary Range: $104,000/yr. - $186,160.00/yr.

St. Jude Benefits

• St. Jude Children's Research Hospital is one of the world's leading pediatric hospitals whose mission is to advance cures for catastrophic childhood diseases.
• Consistent with the vision of our founder, no child is denied treatment based on race, religion, or ability to pay.
• St. Jude has been consistently named one of the best companies to w