Lead Scientist, High-Throughput Bioprocess Purification

Repligen Corporation; Lebanon (NH); On-site; USD 115,000 - 145,000; Full time

Benefits offered by this job

Paid time off

Health/dental/vision

Retirement benefits

Flexible spending accounts

Job summary

Repligen Corporation is seeking a senior scientist to lead the design and optimization of affinity purification technologies for diverse biopharmaceutical modalities. This role blends high-throughput experimentation, data-driven process development, and cross-functional collaboration to deliver purification solutions that accelerate bioprocessing performance.

You will engage with external partners as a technical expert, translate complex data into actionable insights, and contribute to multiple

Qualifications

• MS or PhD in Biochemistry, Chemical Engineering, Biochemical Engineering, or related field.
• Minimum 5 years of hands-on downstream processing and protein purification; including FPLC.
• Experience across multiple modalities (proteins, enzymes, vaccines, VLPs, gene therapy vectors).
• Expertise in chromatography method development, including automated/high-throughput systems.
• Strong proficiency with Design of Experiments (DOE) for process optimization.
• Working knowledge of analytical techniques (purity/impurity, potency, stability).
• Broad scientific understanding spanning separations, protein chemistry, bioprocessing.
• Strong communication skills with the ability to translate data into clear insights.
• Self-motivated, collaborative, and effective in a fast-paced, innovation-driven environment.

Responsibilities

• Design, develop, and optimize affinity chromatography–based purification processes for diverse biopharmaceutical modalities.
• Execute high-throughput chromatographic screening and apply DOE methodologies to accelerate process development.
• Analyze, interpret, and communicate complex datasets to drive decision-making and support partner adoption of new technologies.
• Collaborate cross-functionally with internal teams to deliver integrated purification solutions.
• Contribute to multiple development programs, ensuring timely execution and high-quality scientific output.
• Innovate and propose novel approaches to improve purification performance, selectivity, and scalability.
• Engage with external biopharma partners as a technical expert and scientific collaborator.

Skills

DOE methodologies

Chromatography method development

High-throughput screening

Data interpretation

Cross-functional collaboration

Strong communication

Protein purification

Bioprocessing knowledge

Education

MS or PhD in Biochemistry, Chemical Engineering, Biochemical Engineering, or related field

Tools

FPLC

DOE software

Job description

Repligen Corporation is seeking a senior scientist to lead the design and optimization of affinity purification technologies for diverse biopharmaceutical modalities. This role blends high-throughput experimentation, data-driven process development, and cross-functional collaboration to deliver purification solutions that accelerate bioprocessing performance.

You will engage with external partners as a technical expert, translate complex data into actionable insights, and contribute to multiple