Scientist, High-Throughput Protein Expression and Purification

Scorpion Therapeutics; Brisbane (CA); On-site; USD 90,000 - 130,000; Full time

Job summary

Scorpion Therapeutics is seeking a Scientist specializing in high-throughput biologics production to accelerate discovery workflows for antibody and multispecific programs. You will execute mammalian expression, purification, and quality assessments, while optimizing automated platforms and developing reproducible pipelines.

Collaborate across Protein Sciences, Molecular Biology, Automation, Data Science, and Discovery Biology teams to evaluate new technologies and ensure data integrity and

Qualifications

• Bachelor’s degree in biochemistry, bioengineering, or related field with 5+ years, or master’s with 3+ years, or PhD with relevant experience.
• Hands-on expertise in mammalian expression systems (HEK293/CHO), protein purification, cloning, and high-throughput workflows.
• Strong problem-solving and communication skills.
• Ability to independently design experiments and manage evolving priorities.

Responsibilities

• Execute and optimize scalable mammalian protein expression, purification, normalization, and quality assessment.
• Operate and troubleshoot automation platforms.
• Develop reproducible workflows.
• Collaborate across Protein Sciences, Molecular Biology, Automation, Data Science, and Discovery Biology teams.
• Evaluate emerging technologies for throughput and quality improvements.
• Document and ensure data integrity and safety.

Skills

Problem solving

Communication

Independent experimental design

Team collaboration

Education

Bachelor's degree in biochemistry or bioengineering

Master's degree with relevant experience

PhD with relevant experience

Tools

Python

R

ELN

LIMS

Job description

Role

Scientist specializing in high-throughput biologics production within Discovery Biotherapeutics, supporting antibody and multispecific discovery workflows.

Responsibilities

• execute and optimize scalable mammalian protein expression, purification, normalization, and quality assessment;
• operate and troubleshoot automation platforms;
• develop reproducible workflows;
• collaborate across Protein Sciences, Molecular Biology, Automation, Data Science, and Discovery Biology teams;
• evaluate emerging technologies for throughput and quality improvements;
• document and ensure data integrity and safety.

Requirements

• Bachelor's degree in biochemistry, bioengineering, or related field with 5+ years, or master's with 3+ years, or Ph.D. with relevant experience;
• hands-on expertise in mammalian expression systems (HEK293/CHO), protein purification, cloning, and high-throughput workflows;
• strong problem-solving and communication skills;
• ability to independently design experiments and manage evolving priorities.

Preferred

• experience with laboratory automation, analytical protein quality methods (SEC, HPLC, SDS-PAGE), cell-free expression, workflow scripting (Python, R), and digital data systems (ELN, LIMS).

High-Value

• biologics discovery, therapeutic antibodies, multispecifics;
• workflow automation and scale-up;
• collaboration with cross-functional teams;
• focus on throughput, reproducibility, and continuous improvement.

Work setup

not explicitly specified; role involves laboratory execution, automation, and cross-team interactions.