Oligonucleotide/Peptide Purification Development Scientist

Hydrogen Group; Cambridge (MA); On-site; USD 6,612,000 - 7,577,000; Full time

Job summary

Hydrogen Group is recruiting for an Oligonucleotide/Peptide Purification Development role in Cambridge, MA. The candidate will develop and scale purification processes for oligonucleotide and peptide therapeutics, collaborating across purification, analytical, and manufacturing teams to enable clinical and commercial programs.

Responsibilities include process development, chromatography, UF/DF, and technology transfer to pilot scale and GMP facilities, with opportunities to mentor staff and

Qualifications

• Experience planning and executing scientific projects and experiments.
• Hands-on purification of proteins, peptides, and/or DNA/RNA.
• Knowledge of column chromatography (ion exchange, HIC, RP).
• Experience with UF/DF.
• Analytical skills: HPLC and UV/Vis spectroscopy.
• Creative, technically proficient in purification tech.
• Strong written and verbal communication.
• Ability to work independently and in cross-functional teams.

Responsibilities

• Develop and characterize purification processes for oligonucleotide and peptide therapeutics, including scale‑up.
• Support purification unit operations including chromatography, detritylation, UF/DF.
• Learn or apply chemical cleavage, conjugation, and hybridization steps.
• Investigate purification technologies to improve purity and productivity.
• Contribute to early- and late‑stage process characterization and robustness studies.
• Scale up and transfer purification processes to pilot scale and GMP manufacturing.
• Support technology transfer, document review, troubleshooting, and on‑the‑manufacturing floor work.
• Lead or support pilot‑scale activities and small technical initiatives.
• Provide training and mentoring to new staff.
• Assist in preparing CMC/regulatory sections for IND submissions.

Skills

Purification development

Chromatography

UF/DF

HPLC

UV/Vis spectroscopy

Protein/peptide purification

Technology transfer

Cross-functional teamwork

DoE

ÄKTA purification systems

Education

Bachelor’s degree in Biochemistry, Chemical Engineering, Chemistry, or related life science field

Master’s degree in a related field

Tools

ÄKTA purification systems

UNICORN software

Job description

Hydrogen Group is recruiting for an Oligonucleotide/Peptide Purification Development role in Cambridge, MA. The candidate will develop and scale purification processes for oligonucleotide and peptide therapeutics, collaborating across purification, analytical, and manufacturing teams to enable clinical and commercial programs.

Responsibilities include process development, chromatography, UF/DF, and technology transfer to pilot scale and GMP facilities, with opportunities to mentor staff and