Lead Metabolite Profiling Scientist

Alnylam Pharmaceuticals

United States

On-site

USD 180,000 - 230,000

Full time

6 days ago

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Job summary

Alnylam Pharmaceuticals in the United States seeks a Principal Scientist to lead biotransformation and metabolite profiling, shaping strategies for discovery and development programs. You will oversee metabolite identification across matrices, apply advanced LC-HRMS/MS methods, and drive data interpretation to inform drug disposition and safety.

The role involves collaboration with DMPK, bioanalytical sciences, pharmacology, and toxicology to translate findings into actionable insights for

Qualifications

PhD with 6+ years of industry experience in small molecule/biologics metabolism and metabolite profiling.
Hands-on LC-MS/MS and HRMS data interpretation for metabolite identification.
Proven ability to elucidate biotransformation pathways and metabolite structures.

Responsibilities

Lead metabolite profiling and structural identification in biological matrices.
Apply LC-HRMS/MS for detection, profiling and relative quantitation of metabolites.
Develop biotransformation strategies using hepatocytes and tissue preparations.
Collaborate with cross-functional teams to translate metabolite data into disposition and safety insights.
Author BA reports for in vitro/in vivo metabolite profiling used in IND filings.