Senior Scientist - Biotransformation & Metabolism

BioSpace; North Chicago (IL); On-site; USD 125,000 - 180,000; Full time

Benefits offered by this job

Paid time off

401(k)

Job summary

AbbVie’s Biotransformation and Disposition team seeks a Senior Scientist II to lead in vitro and in vivo biotransformation and ADME studies, guiding project strategies through mass spectrometry, metabolite profiling, and structure elucidation. You will collaborate across disciplines, mentor peers, and contribute to regulatory submissions with robust data interpretation.

Expertise in LC-MS/MS and high-resolution MS, +4 years post-PhD (or equivalent) in small-molecule drug development is required,

Qualifications

• Ph.D. in Chemistry, Life Sciences or a related field with 4+ years; alternatively, a Masters degree with 8+ years or a Bachelor’s degree with 10+ years of relevant experience.

Responsibilities

• Design, conduct, interpret, and report in vitro and in vivo biotransformation studies to identify metabolites, metabolic pathways, and clearance mechanisms.
• Perform metabolite profiling and structural elucidation using LC-MS/MS, high-resolution mass spectrometry, and complementary analytical techniques.
• Develop, optimize, maintain, and troubleshoot chromatographic and mass spectrometric methods, including assays involving radiolabeled compounds where applicable.
• Integrate metabolite data with broader DMPK, ADME, pharmacokinetic, toxicology, chemistry, and clinical findings to support compound selection and development decisions.
• Represent Biotransformation and Disposition on cross-functional project teams and communicate scientific findings through presentations, technical reports, publications, and regulatory documents.
• Evaluate and implement emerging technologies, study designs, automation approaches, and analytical methods to improve data quality, sensitivity, throughput, and scientific impact.
• Collaborate effectively with internal and external partners while maintaining rigorous documentation, data integrity, regulatory compliance, and laboratory safety standards.
• Contribute to a collaborative learning environment by mentoring colleagues, sharing technical expertise, encouraging innovation, and supporting continuous improvement.

Skills

Mass spectrometry

LC-MS/MS

Structure elucidation

Data analysis

Cross-functional collaboration

Regulatory documentation

Education

PhD in Chemistry or Life Sciences

MS with 8+ years of experience

Bachelor’s degree with 10+ years of experience

Tools

Thermo mass spectrometers

Sciex mass spectrometers

Job description

AbbVie’s Biotransformation and Disposition team seeks a Senior Scientist II to lead in vitro and in vivo biotransformation and ADME studies, guiding project strategies through mass spectrometry, metabolite profiling, and structure elucidation. You will collaborate across disciplines, mentor peers, and contribute to regulatory submissions with robust data interpretation.

Expertise in LC-MS/MS and high-resolution MS, +4 years post-PhD (or equivalent) in small-molecule drug development is required,