Senior Scientist I/II - Oncology/Immuno-Oncology

Novartis Group Companies; Cambridge (MA); On-site; USD 99,000 - 183,000; Full time

Benefits offered by this job

Health benefits

401(k) with company match

Paid time off & holidays

Job summary

Novartis is seeking a Senior Scientist to join the Oncology OIT group in Cambridge, MA. You will perform drug discovery work involving immunology, tumor biology, and cell-based assays to identify and validate novel targets.

The role requires hands-on experience with immune cell assays, molecular biology techniques, and collaboration across a matrixed team. The position offers a competitive salary range and comprehensive US benefits; relocation assistance is available.

Qualifications

• Bachelor's degree in immunology, immuno-oncology, oncology, molecular or cell biology, or a related field is required. A master's degree is preferred.
• 5+ years of relevant laboratory experience in industry
• Knowledge of immunology and expertise in cancer biology and/or immunology are required
• Expertise in tumor immunology, especially T cell mediated anti-tumor activity is highly desired
• Proficiency in cell culture including cell lines and primary cells, and multi-color flow cytometry is required.

Responsibilities

• Support drug screening, target identification and validation using replication-incompetent lentiviruses, mRNA-LNP, cell lines, primary cells, and tissues
• Develop and perform cell-based assays, flow cytometry, and biochemistry-based assays for drug discovery; molecular biology techniques (gel electrophoresis, cloning, qPCR, western blot) when needed
• Conduct biological and pharmacological studies by analyzing preclinical tissue samples from the in vivo team
• Maintain good lab practices, data recording, analysis and documentation
• Collaborate effectively in a matrixed environment and present results in lab/department meetings
• Assist in writing research documents and publications

Skills

Immunology

Cancer biology

Tumor immunology

Cell culture

Flow cytometry

Molecular cloning

qPCR

ELISA

Western blot

Viral production

mRNA-LNP

Gene silencing

Education

Bachelor's degree in immunology, biology or related field

Master's degree preferred

Tools

Flow cytometer

qPCR

ELISA

Western blot

Gel electrophoresis

Molecular cloning

Job description

Job Description Summary

Role Type: Onsite Working #LI-Onsite

Location: Cambridge, Massachusetts, United States

Relocation: Relocation assistance is available for this position

Join Novartis Oncology-OIT (Oncology Immune Therapies) group for an exciting opportunity to make a significant impact on cancer immunology. As a key member of our dynamic, multidisciplinary team, you will contribute to the development of groundbreaking therapeutic modalities. Your work will play a crucial role in advancing new therapies and bringing our innovative drugs to patients.

Job Description

Key Responsibilities:

• Support drug screening, novel target identification and validation, including working with replication-incompetent lentiviruses, mRNA-LNP, cell lines, primary cells, and tissues
• Develop and perform cell-based assays, flow cytometry, and biochemistry-based assays for drug discovery.Occasionally, you will also employ molecular biology (e.g. gel electrophoresis, cloning, qPCR, western blot, etc.)
• Conduct biological and pharmacological studies by developing and performing analyses of preclinical tissue samples provided by the in vivo team
• Employ good laboratory practices, data recording, analysis and documentation
• Collaborate effectively while working in a matrixed environment
• Present results in lab and department meetings
• Assist in writing research documents and publications

Essential Requirements:

• Bachelor's degree in immunology, immuno-oncology, oncology, molecular or cell biology, or a related field is required. A master's degree is preferred.
• 5+ years of relevant laboratory experience in industry
• Knowledge of immunology and expertise in cancer biology and/or immunology are required
• Expertise in tumor immunology, especially T cell mediated anti-tumor activity is highly desired
• Proficiency in cell culture including cell lines and primary cells, and multi-color flow cytometry is required.
• Extensive hands-on experience with immune cell-based assays, including primary immune cell isolation, manipulation, phenotyping, and in vitro functional assays, as well as mammalian cell line culture is highly desired.
• Experience with molecular cloning, qPCR, reporter assays, ELISA, viral production and transduction, mRNA-LNP-mediated gene expression in primary cells, gene silencing (RNAi or CRISPR), or other target validation methods is a plus.
• Demonstrated ability to quickly learn and perform in new areas, implement new techniques and instrumentation
• Strong scientific motivation and rigor, with experience independently designing, developing, executing, and troubleshooting cell-based assays for drug discovery, are preferred.
• Excellent presentation, written and verbal communication, and interpersonal skills, with the ability to thrive in a fast-paced, collaborative environment.
• A record of accomplishments with peer-reviewed publications a plus

What We Offer

This is a dual level posting and as such the salary for this position is expected to range between:

Senior Scientist I: $93,800 - $174,200 per year

Senior Scientist II: $98,700 - $183,400 per year

The final salary offered is determined based on factors like, but not limited to, relevant skills and experience, and upon joining Novartis will be reviewed periodically. Novartis may change the published salary range based on company and market factors.

Your compensation will include a performance-based cash incentive and, depending on the level of the role, eligibility to be considered for annual equity awards.

US-based eligible employees will receive a comprehensive benefits package that includes health, life and disability benefits, a 401(k) with company contribution and match, and a variety of other benefits. In addition, employees are eligible for a generous time off package including vacation, personal days, holidays and other leaves.

To learn more about the culture, rewards and benefits we offer our people click here.

EEO Statement

The Novartis Group of Companies are Equal Opportunity Employers. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, sex, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status.

Accessibility and reasonable accommodations

The Novartis Group of Companies are committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or to perform the essential functions of a position, please send an e-mail to [e-mail] or call [phone] and let us know the nature of your request and your contact information. Please include the job requisition number in your message.

Salary Range

$98,700.00 - $183,300.00

Skills Desired

Algorithms, Algorithms, Analytical Skill (Inactive), Analytical Thinking, Chemical Biology, Clinical Research, Clinical Trials, Collaboration, Communication Skills (Inactive), Curious Mindset, Data (Inactive), Data Analysis, Design of Experiments (DOE), Detail-Oriented, Diversity and Inclusion (D&I), Drug Discovery Process, Ethics, Hypothesis Testing, Immunology, Laboratory (Inactive), Leading Project Teams, Lifesciences (Inactive), Mammalian Cell Culture, Medical Research, Molecular Biology {+ 6 more}