Head of Industrial Engineering & Process Optimization

Doist; Portland (OR); On-site; USD 160,000 - 230,000; Full time

Job summary

Twist Bioscience seeks a Sr Manager of Process Optimization & Industrial Engineering in Wilsonville, OR to lead continuous improvement across high-throughput manufacturing. You will drive data-driven improvements, balancing throughput gains with long-term excellence, and partner with Manufacturing, Quality, and Automation Engineering.

You will apply time-motion studies, line balancing, capacity modeling, and value stream mapping to diagnose bottlenecks and optimize resources while ensuring GxP

Qualifications

• Bachelor's or Master's degree in Industrial Engineering, Mechanical Engineering, Manufacturing Engineering, or a related field.
• 8-12+ years of progressive experience in industrial engineering or manufacturing process optimization.
• 3-5+ years in a supervisory, management, or cross-functional team leadership role.
• Experience in ISO 13485 or GxP-regulated environments.
• Strong analytical foundation with OEE, Cpk, takt time, and cost-per-unit modeling.
• Ability to influence cross-functional stakeholders without direct authority.
• Hands-on expertise with core IE tools: time-motion studies, line balancing, capacity modeling, and value stream mapping.

Responsibilities

• Analyze manufacturing line performance data to identify capacity constraints and bottlenecks.
• Investigate first pass rate losses; lead root cause analysis with Quality and Manufacturing.
• Develop and prioritize a pipeline of improvement opportunities with ROI focus.
• Build business cases and ROI models for proposed improvements and capital requests.
• Design and implement process changes using IE tools and validate via pilots.
• Partner with Automation Engineering to scope equipment or automation upgrades.
• Collaborate with Manufacturing and Workforce Planning to right-size staffing.
• Establish and track KPIs (OEE, first pass yield, cycle time, cost-per-unit) to measure impact.
• Ensure changes comply with GxP and document change control with QA.
• Present improvement roadmaps and results to senior leadership.

Skills

OEE

Cpk

Takt time

Line balancing

Value stream mapping

DOE

Cross-functional influence

GxP experience

Capacity modeling

Education

Bachelor's or Master's in Industrial Engineering / Mechanical / Manufacturing Eng

Tools

Time-motion studies

Line balancing

Capacity modeling

Value stream mapping

Job description

Twist Bioscience seeks a Sr Manager of Process Optimization & Industrial Engineering in Wilsonville, OR to lead continuous improvement across high-throughput manufacturing. You will drive data-driven improvements, balancing throughput gains with long-term excellence, and partner with Manufacturing, Quality, and Automation Engineering.

You will apply time-motion studies, line balancing, capacity modeling, and value stream mapping to diagnose bottlenecks and optimize resources while ensuring GxP