Sr Systems Engineer

Twist Bioscience; Portland (ME); On-site; USD 120,000 - 180,000; Full time

Job summary

Twist Bioscience in Portland, OR (onsite in Wilsonville) seeks a Senior Systems Engineer to lead development, validation and integration of automated laboratory instrumentation and bioprocess technologies. You will design automated workflows, write scripts, and connect robotic systems with enterprise LIMS to drive quality.

The role spans hardware/software interfaces, DoE testing, and cross-functional collaboration to ensure cost-effective, compliant processes in a fast-paced environment.

Qualifications

• Ph.D. or MS with 3 years, BS with 5 years in Biomedical Engineering, Chemical Engineering, Mechanical/Electrical Engineering, or related field.
• Experience developing automated instrumentation for bioprocesses.
• Experience with DoE for testing and troubleshooting of processes.
• Experience in designing and writing scripts (C#, Python) for lab automation and cross-integration systems.
• Experience with sample tracking software and interfaces between robotic instrumentation and LIMS systems (MES/Maestro, Twist build).
• Excellent scientific computation and data analysis capabilities.
• Hands-on skills to assemble and maintain hardware.
• Excellent communication and writing skills; able to work in a fast-paced team.

Responsibilities

• Develop, validate, and release new processes and technologies to achieve cost-effectiveness and improved product quality.
• Develop and test protocols, scripts, and systems to automate certain bioprocesses.
• Operate and maintain a range of instruments with a focus on laboratory automation and cross-integration systems.
• Collaborate with multi-disciplinary teams to troubleshoot equipment and system issues.
• Prepare and participate in documentation, knowledge transfer, and training activities.
• Follow regulatory and ISO 13485 requirements.

Skills

Automation experience

Bioprocess instrumentation

C#/Python scripting

LIMS integration

Data analysis

Hardware assembly

Cross-team collaboration

Education

Ph.D. or MS with 3 years, BS with 5 years in Biomedical/Chemical/Mechanical/Electrical Engineering or related field

Tools

Maestro/LIMS

Twist build interfaces

Job description

Sr. Systems Engineer (Onsite in Wilsonville, OR)

Summary

We are seeking a Senior Systems Engineer to join our team in Portland, OR (PDX). In this role, you will lead the development, validation, and integration of cutting-edge automated laboratory instrumentation and bioprocess technologies. Working at the intersection of hardware, software, and biology, you will design automated workflows, write custom integration scripts, and connect robotic systems with enterprise LIMS infrastructure to drive operational excellence and product quality under ISO 13485 standards.

What You’ll Do

• Develop, validate, and release new processes and technologies to achieve cost-effectiveness and improved product quality
• Develop and test protocols, scripts, and systems to automate certain bioprocesses
• Operation and maintenance of a range of scientific instruments and tools with a focus on laboratory automation systems and cross-integration systems
• Collaborate with multi-disciplinary teams in troubleshooting and resolving issues concerning equipment and systems
• Prepare and participate in documentation, knowledge transfer, and training activities
• Follow regulatory and ISO 13485 requirements

What You’ll Bring

• Ph.D. or MS with 3 years, BS with 5 years of related experience in Biomedical Engineering, Chemical Engineering, Mechanical/Electrical Engineering, or related field
• Experience in developing automated instrumentation for bioprocesses
• Experience with DoE for testing and troubleshooting of certain processes
• Experience in designing and writing scripts (C#, Python, etc) using control software or dynamic scheduling software native to laboratory automation systems and cross-integration systems
• Experience with sample tracking software and developed interfaces between robotic instrumentation and LIMS systems (MES/Maestro, Twist build)
• Excellent scientific computation and data analysis capabilities
• Hands-on skills to assemble and maintain hardware
• Experience with biological instrumentation for liquid transfer, PCR, cell-based cloning, DNA extraction, and purification is desirable
• Working collaboratively with other functional groups
• Excellent communication and writing skills, and ability to work in a fast-paced team environment

About Twist Bioscience

Twist Bioscience synthesizes genes from scratch, known as “writing” DNA. Just as children learn to both read and write, the next phase of development for the genomics revolution is the ability to write DNA.

At Twist Bioscience, we work in service of people who are changing the world for the better. In fields such as health care, agriculture, industrial chemicals and data storage, our unique silicon-based DNA Synthesis Platform provides precision at a scale that is otherwise unavailable to our customers.

Twist Bioscience Corporation is an Equal Opportunity Employer. Twist Bioscience Corporation provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, genetic characteristics, or any other category protected by law.