Manufacturing Associate - IgG Production

Twist Bioscience; Portland (ME); On-site; USD 52,000 - 68,000; Full time

Job summary

Twist Bioscience seeks a Manufacturing Associate for IgG Production in a highly automated, high-throughput lab in Wilsonville, OR. You will produce diverse IgG antibody products and follow established SOPs while operating sensitive equipment within a cleanroom environment.

The role emphasizes teamwork, meticulous documentation, and adherence to GMP/ISO practices in a fast-paced startup setting. You will contribute to daily production schedules and reagent handling.

Qualifications

• Associates or Bachelors degree in Biology, Chemistry or related field.
• Relevant experience in manufacturing or lab environment is desirable.
• Good written and verbal skills are critical.
• Proficiency with Excel and basic software is preferred.

Responsibilities

• Manufacture high quality custom products in a high throughput MFG lab according to SOPs.
• Operate lab equipment and liquid handling robots (Hamilton Stars, bioanalyzers, centrifuges, sealers, thermocyclers, spectrometers, Illumina sequencers).
• Apply PCR, DNA quantitation, purification and cloning techniques.
• Maintain thorough, accurate documentation using templates and software.
• Update and write work instructions and documentation.
• Work independently and safely, with attention to detail.
• Assist Leads/Supervisors with troubleshooting and deviations.
• Package/organize products for shipping.
• Follow GMP and ISO practices; support lean manufacturing.
• Complete daily tasks to keep manufacturing schedule on track.

Skills

Molecular biology

PCR

Documentation

High throughput lab

Team collaboration

Communication

Computer skills

Education

Associates or Bachelors degree in Biology, chemistry or related field

Tools

Hamilton Stars

Bioanalyzers

Centrifuges

Thermocyclers

Illumina sequencers

Liquid handling robots

Spectrometers

Job description

We are looking for motivated, enthusiastic individuals to join our Twist Bioscience Operations team in Wilsonville, OR. The Manufacturing Associate, IgG Production, will produce various IgG antibody products, focusing on molecular and cellular biology, as well as running analytic techniques in the high-throughput/highly-automated lab according to established SOPs, along with working with sensitive equipment and following good manufacturing practices. Candidates must also be a team player, neat and highly organized, able to work in a cleanroom environment and foster safe work practices.

The Manufacturing Associate will perform basic reagent handling, chemistry and molecular biology workflows in a highly automated, high-throughput manner and will be responsible for the manufacture and analysis of a variety of custom DNA based intermediates and products across Twist Bioscience’s proprietary process workflow to meet the Twist production forecast and timelines.

The ideal candidate will be driven and will do what it takes to keep manufacturing on track in a fast paced start-up environment. The Manufacturing Associate will be responsible for the production of custom gene based products and/or various intermediates according to established SOPs and complete manufacturing batch records to contribute to the daily production schedule.

Roles and Responsibilities include but are not limited to:

• Manufacture high quality custom products in a high throughput MFG lab according to established SOPs.
• Operate laboratory equipment and liquid handling robots such as Hamilton Stars, bioanalyzers, centrifuges, sealers, thermocyclers, spectrometers, Illumina Next-Gen sequencers etc.)
• Effectively use molecular and cell biology processes and techniques, especially PCR, DNA quantitation, purification and cloning.
• Maintain thorough, accurate and detailed documentation of all work performed using existing document templates and software applications.
• Update and write work instructions and documentation.
• Work independently and in a safe manner.
• Pay great attention to details and perform consistent work without excessive supervision.
• Help Leads and Supervisors with troubleshooting and the handling of process deviations.
• Package and/or organize products for shipping.
• Work according to Good Manufacturing and ISO practices. Learn, adopt and promote lean manufacturing concepts.
• Complete all the daily assigned tasks to keep the manufacturing schedule on track and report back to Lead and Supervisor.

What You’ll Bring to the Team

• Relevant experience that can indicate success in a high throughput, fast pace laboratory manufacturing environment.
• Associates or Bachelors degree in Biology, chemistry or related field is desirable.
• Familiarity or prior experience in a manufacturing and/or a laboratory environment is highly desirable.
• Good written and verbal skills are critical.
• Good computer skills (Excel, Word, Atlassian etc) and the ability to quickly learn new software applications.
• Ability to pay great attention to details.

Working Conditions

• The work will be performed in a very dynamic laboratory team environment.
• It is a controlled laboratory environment.
• Must be able to stand for long periods of time while performing duties.
• Must be able to work safely with chemicals and hazardous materials.
• Must be able to lift up to 20 lbs.
• Must be able to work outside of regular work hours/ work a flexible shift as needed

Possible Shifts:

1.5A: Sunday-Tuesday, Alt Wednesday (2:00pm-2:30am)
1.5B: Alt Wednesday, Thursday-Saturday (2:00pm-2:30am)

About Twist Bioscience

Twist Bioscience synthesizes genes from scratch, known as “writing” DNA. Just as children learn to both read and write, the next phase of development for the genomics revolution is the ability to write DNA.

At Twist Bioscience, we work in service of people who are changing the world for the better. In fields such as health care, agriculture, industrial chemicals and data storage, our unique silicon-based DNA Synthesis Platform provides precision at a scale that is otherwise unavailable to our customers.

Twist Bioscience Corporation is an Equal Opportunity Employer. Twist Bioscience Corporation provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, genetic characteristics, or any other category protected by law.