Global Clinical Ops Transformation & Performance Lead

Vertex Pharmaceuticals Inc (US); Boston (MA); Hybrid; USD 255,000 - 383,000; Full time

Benefits offered by this job

Bonus eligibility

Equity awards

Flexible PTO and holidays

Commuting subsidy

Job summary

Vertex Pharmaceuticals Incorporated is seeking an Executive Director to lead Performance Excellence & Business Transformation for Global Clinical Operations. The role drives end-to-end process optimization, digital capabilities, and governance across a global portfolio, reporting to the Head of Global Clinical Operations as a member of the Leadership team.

You will guide multi-year transformation, streamline planning, enrollment, and data workflows, and embed advanced analytics to monitor

Qualifications

• Bachelor’s degree required in Life Sciences, Engineering, Operations or related field.
• Advanced degree (MS, MPH, PharmD, MBA, PhD) preferred.
• 15+ years of leadership in Global Clinical Operations, R&D Operations, Clinical Development or related functions.
• Proven success driving enterprise transformation and performance excellence in regulated environments.

Responsibilities

• Lead multi-year transformation roadmap to modernize Global Clinical Operations and elevate operational effectiveness.
• Identify enterprise-level opportunities to streamline clinical trial planning, site startup, enrollment, data collection, and closeout.
• Drive harmonization and standardization of GCO processes across regions, therapeutic areas, and CRO partners.
• Develop and oversee governance frameworks for clinical transformation initiatives, including KPIs and benefits realization.
• Collaborate with DTE to accelerate adoption of modern clinical technologies.
• Embed analytics and predictive modeling to identify enrollment risks and optimize decision-making.
• Oversee study and operational metrics, lead dashboard development.
• Lead GCO Resource Strategy and allocation.
• Drive the identification and implementation of novel site and patient-facing technologies, including GMDA RPA.
• Collaborate with CROs, vendors, and partners to ensure performance and efficiency across studies.
• Build and lead a high-performing Transformation/Operational Excellence team.
• Oversee change management strategies for global adoption and sustained results.

Skills

Strategic leadership

Operations optimization

Data analytics

Digital transformation

Stakeholder management

Change management

Cross-functional collaboration

Education

Bachelor’s degree

Advanced degree (MS/MPH/PharmD/MBA/PhD) preferred

Job description

Vertex Pharmaceuticals Incorporated is seeking an Executive Director to lead Performance Excellence & Business Transformation for Global Clinical Operations. The role drives end-to-end process optimization, digital capabilities, and governance across a global portfolio, reporting to the Head of Global Clinical Operations as a member of the Leadership team.

You will guide multi-year transformation, streamline planning, enrollment, and data workflows, and embed advanced analytics to monitor