Global Clinical Ops Leader - Performance & Transformation

Vertex Pharmaceuticals LLC; Boston (MA); Hybrid; USD 255,000 - 383,000; Full time

Benefits offered by this job

Remote-Eligible

Job summary

Vertex Pharmaceuticals in Boston is seeking an Executive Director of Performance Excellence & Business Transformation to drive end-to-end transformation across Global Clinical Operations, leveraging technology, analytics, and regulatory rigor.

The role leads a high‑performing team, partners with CROs and vendors, and shapes governance, KPIs, and workforce strategy to accelerate study delivery while ensuring patient safety.

Qualifications

• Bachelor’s degree required (Life Sciences, Engineering, Operations, or related field).
• Advanced degree (MS, MPH, PharmD, MBA, PhD) preferred.
• 15+ years of increasing leadership responsibility in Global Clinical Operations, R&D Operations, Clinical Development, or related functions within pharma, biotech, or CRO.
• Proven success driving enterprise transformation and performance excellence initiatives within highly regulated environments.
• Strong track record improving clinical trial cycle times, quality, and operational predictability.
• Experience implementing digital, data, or technology solutions for clinical operations.

Responsibilities

• Lead the creation and execution of a multi-year transformation roadmap to modernize Global Clinical Operations and elevate operational effectiveness.
• Identify enterprise-level opportunities to streamline clinical trial planning, site startup, enrollment, data collection, data cleaning, and closeout.
• Drive harmonization and standardization of GCO processes across regions, therapeutic areas, and CRO partners.
• Develop and oversee governance frameworks for clinical transformation initiatives, including prioritization, KPIs, and benefits realization.
• Collaborate with DTE to accelerate adoption of modern clinical technologies
• Embed advanced analytics and predictive modeling to identify enrollment risks, monitor site performance, and optimize operational decision-making.
• Oversee study and operational metrics, lead dashboard development
• Lead GCO Resource Strategy and allocation
• Drive the identification, implementation, and development of novel site and patient-facing technologies, including support for end-to-end technology deployment and GMDA robotic process automation
• Collaborate with external CROs, vendors, and strategic partners to ensure operational performance, consistency, and efficiency across outsourced studies.
• Build and lead a high-performing Transformation/Operational Excellence team within GCO.
• Oversee change management strategies to ensure global adoption, behavior change, and sustained results.

Skills

Strategic leadership

Transformation programs

Stakeholder engagement

Clinical analytics

Regulatory compliance

Education

Bachelor’s degree

Advanced degree preferred

Job description

Vertex Pharmaceuticals in Boston is seeking an Executive Director of Performance Excellence & Business Transformation to drive end-to-end transformation across Global Clinical Operations, leveraging technology, analytics, and regulatory rigor.

The role leads a high‑performing team, partners with CROs and vendors, and shapes governance, KPIs, and workforce strategy to accelerate study delivery while ensuring patient safety.