Executive Director, Global Transformation & Performance

Vertex Pharmaceuticals Incorporated; United States; Remote; USD 255,000 - 383,000; Full time

Benefits offered by this job

Annual bonus

Equity awards

Job summary

Vertex Pharmaceuticals Incorporated is seeking an Executive Director of Performance Excellence & Business Transformation for Global Clinical Operations. You will drive end-to-end transformation, build digital capabilities, and lead analytics and governance across a global trial portfolio to improve delivery, quality, and compliance.

Reporting to the Head of GCO, you will influence strategy, lead high‑performing teams, collaborate with CROs and vendors, and advance AI/ML initiatives while

Qualifications

• Bachelor’s degree in Life Sciences, Engineering, Operations, or related field required.
• Advanced degree (MS, MPH, PharmD, MBA, PhD) preferred.
• 15+ years of increasing leadership responsibility in GCO, R&D ops, or related pharma/biotech functions.
• Proven success driving enterprise transformation and performance excellence in regulated environments.
• Strong track record improving trial cycle times, quality, and operational predictability.
• Experience implementing digital, data, or technology solutions for clinical operations.

Responsibilities

• Lead multi-year transformation roadmap to modernize Global Clinical Operations.
• Identify enterprise-level opportunities to streamline planning, site start-up, enrollment, data collection, and closeout.
• Drive harmonization and standardization of GCO processes across regions and CROs.
• Develop governance frameworks for transformation initiatives with KPIs and benefits realization.
• Collaborate with DTE to accelerate adoption of modern clinical technologies.
• Embed analytics and predictive modeling to identify enrollment risks and optimize decisions.
• Oversee study and operational metrics and lead dashboard development.
• Lead GCO Resource Strategy and allocation.
• Champion site and patient-facing technologies and end-to-end tech deployment.

Job description

Vertex Pharmaceuticals Incorporated is seeking an Executive Director of Performance Excellence & Business Transformation for Global Clinical Operations. You will drive end-to-end transformation, build digital capabilities, and lead analytics and governance across a global trial portfolio to improve delivery, quality, and compliance.

Reporting to the Head of GCO, you will influence strategy, lead high‑performing teams, collaborate with CROs and vendors, and advance AI/ML initiatives while