Downstream Bioprocess Scientist - Early-Phase

jj; Malvern (Chester County); On-site; USD 70,000 - 95,000; Full time

Job summary

Johnson & Johnson in Malvern, PA is seeking an Associate Scientist, Downstream Processing to support biologics purification for early-phase development. You will design, execute, and document bench-scale experiments for chromatography and filtration, ensuring data integrity and regulatory compliance.

You will work cross-functionally with upstream, analytical, formulation, and manufacturing teams to advance programs, transfer technologies, and contribute to process characterization and scale-up.

Qualifications

• B.S or M.S in Chemical Engineering, Biochemistry, Biotechnology, or related field with relevant experience.
• Familiarity with protein purification, bioprocessing, or related methodology.
• Strong written and verbal communication, highly organized, team player.

Responsibilities

• Define work packages and purification strategies for NME candidates in early phase manufacturing.
• Execute chromatography and filtration experiments focusing on product quality and recovery.
• Assist in process characterization, scale-up, and tech transfer of downstream operations.
• Collaborate with upstream, analytical development, formulation, and manufacturing teams to meet timelines.
• Author and review technical or regulatory documents.
• Maintain accurate records and comply with safety and company policies.
• Capture data and maintain records in compliance with cGLP and EHSS requirements.

Skills

Analytical Reasoning

Biochemistry

Chemistry

Manufacturing

CMC

Clinical Trial Protocols

Collaboration

Data Quality

Drug Discovery Development

Execution Focus

Molecular Diagnostics

Pharmacogenetics

Problem Solving

Research Documents

Scientific Research

Technologically Savvy

Troubleshooting

Written Expression

Education

B.S degree in Chemical Engineering, Biochemistry, Biotechnology, or related discipline

M.S degree in Chemical Engineering, Biochemistry, Biotechnology, or related discipline

Tools

AKTA FPLC

JMP

Minitab

Job description

Johnson & Johnson in Malvern, PA is seeking an Associate Scientist, Downstream Processing to support biologics purification for early-phase development. You will design, execute, and document bench-scale experiments for chromatography and filtration, ensuring data integrity and regulatory compliance.

You will work cross-functionally with upstream, analytical, formulation, and manufacturing teams to advance programs, transfer technologies, and contribute to process characterization and scale-up.