Discovery ADME Project Leader: Translational PK/PD Strategy

Eli Lilly and Company; Louisville (CO); On-site; USD 177,000 - 308,000; Full time

Job summary

Eli Lilly and Company is seeking a Discovery ADME Project Leader open to Boston, Louisville, or Indianapolis. The role requires leading preclinical ADME strategy, integrating biology, chemistry, and modeling to inform dose selection and study design.

The successful candidate will have a PhD in a related field and 3+ years in drug discovery, with strong communication and leadership skills to drive cross-functional collaborations and ensure programs advance The Right Molecule to The Right Study at

Qualifications

• PhD in Pharmaceutical Sciences or related field.
• 3+ years post-graduation industry experience in drug discovery.
• Deep ADME expertise with knowledge of medicinal chemistry is advantageous.
• Exceptional written and verbal communication; ability to navigate ambiguity and collaborate globally.
• Ability to translate complex concepts into strategic value for senior leadership.

Responsibilities

• Develop and execute integrated preclinical ADME strategies aligned with discovery stage and regulatory expectations.
• Integrate ADME and pharmacology to enable translational simulations and modeling for dose selection and PK/PD designs.
• Define profiling, decision funnels, and translational modeling appropriate to modality and stage.
• Guide compound design and optimization using data-driven principles (clearance, permeability, solubility, DDI risk).
• Serve as the ADME single point of accountability on cross-functional teams; translate findings into design/test hypotheses.
• Collaborate with Medicinal Chemistry, DMPK, Toxicology, Pharmacology to drive candidate selections; support go/no-go decisions with PK/PD data.

Skills

ADME expertise

Cross-functional collaboration

Communication skills

Strategic leadership

Education

PhD in Pharmaceutical Sciences / Pharmacology / Toxicology

Job description

Eli Lilly and Company is seeking a Discovery ADME Project Leader open to Boston, Louisville, or Indianapolis. The role requires leading preclinical ADME strategy, integrating biology, chemistry, and modeling to inform dose selection and study design.

The successful candidate will have a PhD in a related field and 3+ years in drug discovery, with strong communication and leadership skills to drive cross-functional collaborations and ensure programs advance The Right Molecule to The Right Study at