Discovery ADME Project Leader — Translational PK/PD Strategy

Initial Therapeutics, Inc.; Indianapolis (IN); On-site; USD 177,000 - 308,000; Full time

Benefits offered by this job

Bonus program

401(k) plan

Medical, dental, vision benefits

Well-being programs

Job summary

Initial Therapeutics, Inc. invites applications for a Discovery ADME Project Leader to drive mechanistic drug disposition strategies across discovery programs. You will integrate biology, chemistry, and modeling to design and de-risk new molecules with PK translational insights.

The role requires a PhD and 3+ years in drug discovery, with strong leadership, cross-functional collaboration, and excellent written and verbal communication to influence senior leadership and project teams.

Qualifications

• PhD (or equivalent) in Pharmaceutical Sciences, Pharmacokinetics, Pharmacometrics, Systems Pharmacology, Preclinical or Clinical Pharmacology, Drug Metabolism, Toxicology, Chemical Biology, or related field.

Responsibilities

• Develop integrated preclinical ADME strategies aligned with discovery stage and regulatory expectations.
• Integrate ADME and pharmacology to enable translational simulations and modeling for dose selection and PK/PD design.
• Define profiling, decision funnels, and translational modeling to advance candidates.

Skills

ADME expertise

Project leadership

Scientific communication

Cross-functional collaboration

Pharmacokinetics

Education

PhD in Pharmaceutical Sciences or related field

Tools

AI tools

Job description

Initial Therapeutics, Inc. invites applications for a Discovery ADME Project Leader to drive mechanistic drug disposition strategies across discovery programs. You will integrate biology, chemistry, and modeling to design and de-risk new molecules with PK translational insights.

The role requires a PhD and 3+ years in drug discovery, with strong leadership, cross-functional collaboration, and excellent written and verbal communication to influence senior leadership and project teams.