Discovery ADME Lead: Translational PK/PD Strategy

Scorpion Therapeutics; Boston (MA); On-site; USD 140,000 - 190,000; Full time

Job summary

Scorpion Therapeutics is seeking a Discovery ADME Project Leader to deliver a deep mechanistic understanding of drug disposition and translational PK/PD modeling that informs dose selection and study design. You will integrate biology, chemistry, and modeling within cross-functional discovery teams, guiding go/no-go decisions and regulatory-aligned strategies.

The role requires a PhD in a related field and 3+ years in drug discovery, with emphasis on ADME strategy, data interpretation, and

Qualifications

• PhD (or equivalent) in Pharmaceutical Sciences, Pharmacokinetics, Pharmacometrics, Systems Pharmacology, Preclinical/Clinical Pharmacology, Drug Metabolism, Toxicology, Chemical Biology, or related field.

Responsibilities

• Provide deep mechanistic understanding of drug disposition, PK, and translational science to advance Target Product Profiles.
• Develop and execute integrated preclinical ADME strategies aligned with discovery stage and regulatory expectations.
• Integrate ADME and pharmacology to enable translational simulations/modeling for dose selection and PK/PD design.

Skills

Leadership

Cross-functional collaboration

PK/PD modeling

AI tools

Education

PhD in Pharmaceutical Sciences or related field

Tools

AI tools

Job description

Scorpion Therapeutics is seeking a Discovery ADME Project Leader to deliver a deep mechanistic understanding of drug disposition and translational PK/PD modeling that informs dose selection and study design. You will integrate biology, chemistry, and modeling within cross-functional discovery teams, guiding go/no-go decisions and regulatory-aligned strategies.

The role requires a PhD in a related field and 3+ years in drug discovery, with emphasis on ADME strategy, data interpretation, and