Discovery ADME Project Leader

Scorpion Therapeutics; Louisville (CO); On-site; USD 130,000 - 185,000; Full time

Benefits offered by this job

401(k)

Vacation

Medical/dental/vision

Flexible benefits

Life insurance

Job summary

Scorpion Therapeutics seeks a Discovery ADME Project Leader to drive preclinical ADME strategy across discovery programs. You will integrate ADME with pharmacology to support translational modeling for dose selection, PK/PD design, and safety studies.

You will lead cross-functional teams, mentor scientists, and ensure regulatory-compliant documentation while pursuing innovation and automation in data reporting and decision-making.

Qualifications

• PhD (or equivalent) in Pharmaceutical Sciences or related field.
• 3+ years post-graduation industry experience in drug discovery with leadership impact.

Responsibilities

• Keep Safety as a priority.
• Develop and execute integrated preclinical ADME strategies aligned with discovery stage, TPP, design hypotheses, and regulatory expectations.
• Integrate ADME and pharmacology to enable translational simulations/modeling for dose selection, PK/PD design, efficacy, and safety studies.
• Define stage-, modality-, and issue-appropriate profiling and decision funnels (in silico, in vitro, in vivo to translational modeling).
• Guide compound design/optimization using data-driven principles (clearance, permeability, solubility, DDI risk, transporter liabilities).
• Serve as ADME strategy and single-point-of-accountability on cross-functional program teams; translate ADME findings into design/test hypotheses.
• Collaborate with Medicinal Chemistry, DMPK, Toxicology, Pharmacology, and other Discovery functions; support go/no-go decisions using quantitative PK/PD, IVIVE, and mechanistic interpretation.
• Represent ADME in portfolio governance and leadership reviews.
• Implement best practices, assay innovation, and automation; drive continuous improvement in data reporting/knowledge/decision frameworks; leverage AI/agentic tools where possible.
• Maintain inspection-ready documentation aligned with regulatory expectations.
• Mentor, teach, and grow junior scientists.

Skills

ADME expertise

PK/PD modeling

Cross-functional leadership

Drug discovery experience

Education

PhD in Pharmaceutical Sciences or related field

Job description

Job Title: Discovery ADME Project Leader

What You Will Do

• Keep Safety as a priority.
• Develop and execute integrated preclinical ADME strategies aligned with discovery stage, target product profile (TPP), design hypotheses, and regulatory expectations.
• Integrate ADME and pharmacology to enable translational simulations/modeling for dose selection, PK/PD design, efficacy, and safety studies.
• Define stage-, modality-, and issue-appropriate profiling and decision funnels (in silico, in vitro, in vivo to translational modeling).
• Guide compound design/optimization using data-driven principles (clearance, permeability, solubility, DDI risk, transporter liabilities).
• Serve as ADME strategy and single-point-of-accountability on cross-functional program teams; translate ADME findings into design/test hypotheses.
• Collaborate with Medicinal Chemistry, DMPK, Toxicology, Pharmacology, and other Discovery functions; support go/no-go decisions using quantitative PK/PD, IVIVE, and mechanistic interpretation.
• Represent ADME in portfolio governance and leadership reviews.
• Implement best practices, assay innovation, and automation; drive continuous improvement in data reporting/knowledge/decision frameworks; leverage AI/agentic tools where possible.
• Maintain inspection-ready documentation aligned with regulatory expectations.
• Mentor, teach, and grow junior scientists.

Qualifications

• PhD (or equivalent) in Pharmaceutical Sciences, Pharmacokinetics, Pharmacometrics, Systems Pharmacology, Preclinical/Clinical Pharmacology, Drug Metabolism, Toxicology, Chemical Biology, or related field.
• 3+ years post-graduation industry experience in drug discovery; leadership impact on discovery lifecycle (Design, Make, Test, Analyze).

Additional Qualifications (Preferred)

• Deep ADME expertise; working knowledge of medicinal chemistry and Toxicology principles.
• Experience translating technical concepts into strategic value for senior leadership and cross-functional partners.

Geography: Boston MA, Louisville CO, or Indianapolis IN.

Benefits (if eligible)

• 401(k), pension, vacation, medical/dental/vision/prescription benefits, flexible benefits, life insurance/death benefits, time off/leave, well-being benefits (EAP, fitness, employee clubs/activities).