CNS Histology Specialist - IHC/ISH & Image Analysis

Arbor Biotechnologies; Cambridge (MA); On-site; USD 85,000 - 95,000; Full time

Benefits offered by this job

Bonus and equity for new hire

12 weeks parental leave

Parking or transit support

401(k) match

Discretionary time off

Medical, dental, and vision premium支

Job summary

Arbor Biotechnologies is seeking a histology scientist to develop, optimize, and run CNS tissue assays (IHC, IF, RNAscope). You will process and image rodent and non-human primate samples, quantify readouts, and generate data to inform biodistribution, target engagement, and safety for CNS gene editing programs.

You will analyze results with HALO/QuPath/ImageJ, present findings in group meetings, and help plan endpoints for in vivo studies, while maintaining thorough records and experiment

Qualifications

• 3+ years of industry experience with histology assays (IHC/IF/ISH).
• Experience with CNS tissue from rodent models; NHP experience preferred.
• Quantitative image analysis using HALO, QuPath, or ImageJ/Fiji.
• Strong record-keeping and data presentation for project teams.
• Experience with gene therapy or CNS programs preferred.

Responsibilities

• Develop, optimize, and run IHC, IF, and ISH/RNAscope assays on CNS tissue.
• Process, stain, and image CNS tissue from rodent and NHP studies.
• Quantify assay readouts in image analysis software such as HALO, QuPath, or ImageJ/Fiji.
• Generate histology data to assess biodistribution, target engagement, PD activity, editing outcomes, and safety.
• Analyze and graph results in GraphPad Prism and summarize for project scientists.
• Plan histology endpoints and tissue readouts for in vivo studies with the study lead.
• Present results in group meetings and cross-functional discussions.
• Troubleshoot assays, improve workflows, and maintain records and sample tracking accurately.

Job description

Arbor Biotechnologies is seeking a histology scientist to develop, optimize, and run CNS tissue assays (IHC, IF, RNAscope). You will process and image rodent and non-human primate samples, quantify readouts, and generate data to inform biodistribution, target engagement, and safety for CNS gene editing programs.

You will analyze results with HALO/QuPath/ImageJ, present findings in group meetings, and help plan endpoints for in vivo studies, while maintaining thorough records and experiment