Senior Research Associate, Histology

Arbor Biotechnologies; Cambridge (MA); On-site; USD 85,000 - 95,000; Full time

Benefits offered by this job

Bonus and equity for new hire

12 weeks parental leave

Parking or transit support

401(k) match

Discretionary time off

Medical, dental, and vision premium支

Job summary

Arbor Biotechnologies is seeking a histology scientist to develop, optimize, and run CNS tissue assays (IHC, IF, RNAscope). You will process and image rodent and non-human primate samples, quantify readouts, and generate data to inform biodistribution, target engagement, and safety for CNS gene editing programs.

You will analyze results with HALO/QuPath/ImageJ, present findings in group meetings, and help plan endpoints for in vivo studies, while maintaining thorough records and experiment

Qualifications

• 3+ years of industry experience with histology assays (IHC/IF/ISH).
• Experience with CNS tissue from rodent models; NHP experience preferred.
• Quantitative image analysis using HALO, QuPath, or ImageJ/Fiji.
• Strong record-keeping and data presentation for project teams.
• Experience with gene therapy or CNS programs preferred.

Responsibilities

• Develop, optimize, and run IHC, IF, and ISH/RNAscope assays on CNS tissue.
• Process, stain, and image CNS tissue from rodent and NHP studies.
• Quantify assay readouts in image analysis software such as HALO, QuPath, or ImageJ/Fiji.
• Generate histology data to assess biodistribution, target engagement, PD activity, editing outcomes, and safety.
• Analyze and graph results in GraphPad Prism and summarize for project scientists.
• Plan histology endpoints and tissue readouts for in vivo studies with the study lead.
• Present results in group meetings and cross-functional discussions.
• Troubleshoot assays, improve workflows, and maintain records and sample tracking accurately.

Job description

Why this role matters.

Before any of our CNS gene editing programs can move toward the clinic, we need to see in tissue where an editor went, whether it reached its target, and what it did there. This role produces that evidence. You’ll run and quantify the histology assays on rodent and non-human primate tissue that our program teams use to decide what moves forward.

This role reports to the Senior Scientist, In Vivo Pharmacology. It is on-site in Cambridge, typically 4-5 days per week.

What you’ll own.

• Develop, optimize, and run IHC, IF, and ISH/RNAscope assays on preclinical CNS tissue.
• Process, stain, and image CNS tissue from rodent and non-human primate studies.
• Quantify assay readouts in image analysis software such as HALO, QuPath, or ImageJ/Fiji.
• Generate the histology data used to assess biodistribution, target engagement, pharmacodynamic activity, editing outcomes, and safety.
• Analyze and graph results in GraphPad Prism and summarize them clearly for project scientists.
• Plan histology endpoints and tissue readouts for in vivo studies with the study lead.
• Present results in group meetings and cross-functional study discussions.
• Troubleshoot assays, improve workflows, and keep experimental records and sample tracking accurate.

What you’ve done.

• Bachelor’s degree in biology, neuroscience, pharmacology, or a related field with 3+ years of industry experience, or a master’s degree with 1+ year.
• Has developed, optimized, and run IHC, IF, or ISH/RNAscope assays; automated staining platform experience preferred.
• Has worked with CNS tissue from rodent models; non-human primate tissue experience preferred.
• Has performed quantitative image analysis of CNS histology or ISH readouts in HALO, QuPath, ImageJ/Fiji, or a comparable tool.
• Has kept detailed experimental records and presented data to a project team.
• Has worked on gene therapy, gene editing, AAV, or CNS programs (preferred).

What you’ll get**.**

The anticipated base salary range for this role is $85,000-$95,000. Actual pay depends on relevant experience, skills, education, internal equity, and other job-related factors.

Every employee is eligible for a bonus and new hire equity. We pay about 90% of medical, dental, and vision premiums and fund the full deductible on our HSA plan. You’ll also get 12 weeks of parental leave at full pay, paid parking or transit, a 401(k) match, and discretionary time off.

Arbor is an equal opportunity employer. We’re committed to a hiring process and a workplace free of bias and discrimination, and we welcome candidates of every background.