Biotransformation Scientist — Drug Metabolism & MS Expert

Inotiv, Inc.; St. Louis (MO); Hybrid; USD 90.000 - 130.000; Vollzeit

Benefits dieser Stelle

Health and dental coverage

401K with company match

Paid time off

Zusammenfassung

Inotiv is seeking a Biotransformation Scientist to identify enzymatic pathways metabolizing drug candidates using LC–MS/MS and HRMS in preclinical models, including human tissues. The role supports development of in vitro–to–in vivo relationships for drug clearance and half-life, collaborating with Pharmacology and Toxicology leadership to establish NAMs and screening capabilities.

The candidate should have advanced mass spectrometry expertise, strong data analysis skills, and experience in

Qualifikationen

• PhD in Organic Chemistry, Biochemistry, Analytical Chemistry or related discipline with 2-5 years direct industrial biotransformation experience following Post Doctoral training
• MSc in a discipline described with 5-7 years direct industrial biotransformation experience
• Working command of in vitro kinetic analysis and utilization of contemporary mathematical models to analyze, interpret and/or model drug clearance, predicted half life, and drug-drug interactions
• Ability to perform mass spectrometry data collection, analysis and interpretation via LC-MS/MS

Aufgaben

• Design and execute laboratory studies to identify enzymatic pathways that metabolize small molecules, peptides, and oligonucleotides using contemporary methodologies.
• Investigate primary drug clearance mechanisms in vitro and establish in vitro-to-in vivo correlations for anticipated human half-life.
• Collaborate with in vivo pharmacology and toxicology teams to conduct ADME studies and assess disposition of drug candidates.
• Study exonuclease/endonuclease and peptidase metabolism for oligonucleotide and peptide drugs.
• Develop cellular models of drug metabolism and predictive toxicologic mechanisms with Toxicology leadership.

Kenntnisse

Mass spectrometry

Ausbildung

PhD in Organic Chemistry, Biochemistry, Analytical Chemistry or related

MSc in related discipline

Tools

LC-MS/MS

HRMS

Jobbeschreibung

Inotiv is seeking a Biotransformation Scientist to identify enzymatic pathways metabolizing drug candidates using LC–MS/MS and HRMS in preclinical models, including human tissues. The role supports development of in vitro–to–in vivo relationships for drug clearance and half-life, collaborating with Pharmacology and Toxicology leadership to establish NAMs and screening capabilities.

The candidate should have advanced mass spectrometry expertise, strong data analysis skills, and experience in