Biomarker Lab Leader — Translational Science Director

Novartis AG; Pennsylvania; On-site; USD 153,000 - 283,000; Full time

Benefits offered by this job

Hybrid working options

14 weeks paid parental leave

Insurance plans

Job summary

Novartis AG is seeking a Sr Principal Scientist / Associate Director, Biomarker Assay Development Laboratory in Cambridge, MA. You will lead a high-performing team developing innovative biomarker assays shaping decisions across drug discovery and clinical development.

The role spans renal, liver, fibrosis and emerging diseases, demanding scientific leadership, strategic thinking and collaboration with Translational Medicine, Data Science, and project teams.

Qualifications

• PhD/MD or equivalent in life sciences.
• Extensive biomarker assay development experience in pharma/biotech.
• Deep expertise in cellular, circulating, proteomic, genetic and genomic biomarkers.
• Proven experience designing, qualifying, and implementing assays for preclinical/clinical studies.
• Strong experience with PCR, NGS, immunoassays and mass spectrometry.
• Demonstrated ability to lead and inspire teams in complex organizations.
• Experience managing external partners and CROs.

Responsibilities

• Lead development and qualification of biomarker assays across discovery to clinical development.
• Design fit-for-purpose assay strategies for target engagement and pharmacodynamics.
• Drive laboratory operations, resource planning, and prioritization.
• Build, mentor, and develop a high-performing team of biomarker scientists.
• Foster a culture of scientific excellence, accountability, collaboration, and continuous improvement.
• Partner with Translational Medicine, Data Science, and cross-functional teams on biomarker strategies.
• Establish and manage external collaborations to access emerging technologies.
• Oversee outsourced assay activities and ensure high-quality translational data.
• Provide scientific leadership informing translational plans and clinical strategies.
• Represent the laboratory in cross-functional forums and contribute to program decisions.

Skills

Biomarker assay development

Leadership

Cross-functional collaboration

Scientific communication

Contract research management

Education

PhD/MD in life sciences

Tools

PCR

Next-generation sequencing

Immunoassays

Mass spectrometry

Job description

Novartis AG is seeking a Sr Principal Scientist / Associate Director, Biomarker Assay Development Laboratory in Cambridge, MA. You will lead a high-performing team developing innovative biomarker assays shaping decisions across drug discovery and clinical development.

The role spans renal, liver, fibrosis and emerging diseases, demanding scientific leadership, strategic thinking and collaboration with Translational Medicine, Data Science, and project teams.