Principal Scientist: Biomarker Assay Development & Translational

Novartis AG; Pennsylvania; On-site; USD 109,000 - 234,000; Full time

Benefits offered by this job

Performance-based cash incentive

Eligibility for annual equity awards

Comprehensive benefits package

Job summary

Novartis Biomedical Research in Cambridge, MA is seeking a Principal Scientist I/II to drive bench research in biomarker assay development for DAx programs. This role focuses on designing, developing, and qualifying LBA-based biomarker assays to support target engagement and patient stratification.

The position requires a PhD or MD with 4+ years (or BS/MS with 8+ years) in a relevant field and hands-on expertise in LBA assay development, proteomics, and genomics.

Qualifications

• PhD or MD with 4+ years experience in scientific and technical discipline of relevant field, or BS/MS with 8+ years in relevant field.
• Hands-on experience with designing and executing LBA assays.
• Demonstrated experience in biomarker assay development, proteomics, genetics, genomics, or related fields within pharma or biotech.

Responsibilities

• Design, develop, and qualify preclinical and clinical biomarker assays to support target engagement, pharmacodynamics, and patient stratification for DAx programs.
• Develop and implement ligand binding assays (e.g. ELISA, MSD, immunoassays) with analytical rigor and fit-for-purpose performance.
• Execute laboratory-based research including hands-on assay development, optimization, and troubleshooting.
• Analyze and interpret experimental data with scientific rigor and reproducibility.
• Collaborate with Translational Medicine, Biomarker Development, and DAx project teams to align assay strategies with priorities.
• Support implementation of biomarker assays in preclinical and clinical studies, including documentation and reporting of results.
• Maintain exemplary laboratory practices and adherence to safety and regulatory guidelines.
• Present research findings in lab meetings and contribute to publications and internal reports.

Skills

Biomarker assay development

LBA assay design

Data analysis

Communication skills

Team collaboration

Education

PhD or MD in relevant field with 4+ years

BS/MS with 8+ years in relevant field

Tools

ELISA

MSD

Immunoassays

RNA assays

LC-MS

Job description

Novartis Biomedical Research in Cambridge, MA is seeking a Principal Scientist I/II to drive bench research in biomarker assay development for DAx programs. This role focuses on designing, developing, and qualifying LBA-based biomarker assays to support target engagement and patient stratification.

The position requires a PhD or MD with 4+ years (or BS/MS with 8+ years) in a relevant field and hands-on expertise in LBA assay development, proteomics, and genomics.