Translational Medicine Director — Neurodegeneration & Early Trials

Novartis AG; Pennsylvania; On-site; USD 249,000 - 462,000; Full time

Job summary

Novartis AG is seeking a Director to lead Translational Medicine in Cambridge, MA. The role focuses on developing integrated translational strategies across neurodegeneration, guiding programs from preclinical to early clinical development, and ensuring a strong link between target biology, biomarkers, and clinical endpoints.

You will drive biomarker and endpoint strategy, collaborate with cross‑functional teams, and participate in external scientific leadership to advance patient‑centered

Qualifications

• MD, neurology or clinical training in neurodegenerative diseases.
• Experience in translational medicine, early clinical development, or experimental therapeutics.
• Ability to shape development strategies, execute early clinical studies, and influence regulatory packages.

Responsibilities

• Define and execute integrated translational strategies across neurodegeneration programs.
• Lead translational components from preclinical to Phase 1/2 clinical studies.
• Drive program progression through key decision gates (IND, TDP, IDPA).
• Ensure mechanistic linkage between target biology, biomarkers, and clinical endpoints.
• Collaborate with biomarker development toward validation of molecular biomarkers, functional endpoints, PROs.
• Co-lead design and execution of early clinical studies; define dose escalation and exposure‑response frameworks.
• Lead cross‑functional translational medicine representation within global project teams.

Skills

Translational medicine experience

Early clinical development experience

Neurology / neurodegeneration domain

Education

MD, Neurology

PhD/PharmD in Neuroscience

Job description

Novartis AG is seeking a Director to lead Translational Medicine in Cambridge, MA. The role focuses on developing integrated translational strategies across neurodegeneration, guiding programs from preclinical to early clinical development, and ensuring a strong link between target biology, biomarkers, and clinical endpoints.

You will drive biomarker and endpoint strategy, collaborate with cross‑functional teams, and participate in external scientific leadership to advance patient‑centered